Enso Ventures United States

Enso Ventures is a Venture Capital firm that was founded in 2010 and based in London with an additional office in New York. The firm is looking to provide equity capital to high growth companies in the life science space. The firm is currently interested in companies located in Europe, Russia and the US and is looking to make approximately 2-3 investments over the next 6-9 months.

Sergei Petukhov
Partner 

Excel Venture Management United States

Excel Venture Management is a venture capital firm that was founded in 2008 and is based in Boston, Massachusetts. The firm has managed one fund with committed capital of $125 million, and the firm is currently raising the second fund. Excel Venture Management seeks to make equity investments into life science companies from early to late stages. The typical investment size ranges from $3 million to $ 5million. The firm plans to invest in 4-5 companies over the next 6-9 months and prefers to invest in companies based in US.

Year Founded
2008
Investor Type
Medtech Phase of Development
Capital Structure Preference
Investment Stage Preference
Eric Zimmerman
Kevin Liang

Flagship Ventures

Flagship Ventures is an early-stage venture capital firm founded in 2 and located in Cambridge MA. The firm has $9 million AUM. Flagship Ventures invests in therapeutics and in medical technology and makes initial allocation of typically $5-$5 million with the possibility of follow-on investments for a total commitment of up to $7 million-$15 million.
David Berry
Partner 

Formula Pharma United States

Formula Pharmaceuticals is a US-based oncology focused biotech company, developing Chimeric Antigen Receptor (CAR) based therapies using a proprietary platform.

Formula's CAR therapies involve allogeneic immune effector cells and a NON-viral transfection method for highly efficient cell expansion and differentiation. Additionally, Formula's target effector cells primarily involve Cytokine Induced Killer cells, instead of T-cells or Natural Killer cells. These various characteristics offer distinct practical, clinical, regulatory and commercial benefits over other CAR approaches that involve autologous cells and viral transfection methods. Although not yet in clinical stage development, Formula believes that its CAR based development program will catch up with competing clinical-stage development programs, based on the significant CMC and regulatory advantages that Formula's CAR approach offers.

Formula is interested in meeting with investors and prospective pharmaceutical/biotech partners. Near-term value driving milestones (including clinical trial results) are expected within the next 2-3 years.

Significant industry and investor interest in CAR based therapies have been established over the past 12 months, with 4 leading industry players (Pfizer; Novartis; Celgene and Juno Therapeutics). Formula's CAR therapy is distinctive, and is believed to offer significant advantages of the aforementioned CAR technologies. CARs represent a new and important paradigm for cancer therapy, with the leading pharmaceutical players expected to acquire and develop their own position into this space.

Year Founded
2009
Biotech Subsector
Biotech Phase of Development
Technology Overview
Formula's lead program involves a distinctive approach for the development of Chimeric Antigen Receptor (CAR) based therapies. Formula's proprietary platform involves allogeneic immune cells and NON-viral transfection for the develoment of CAR therapies, using primarily Cytokine Induced Cells (CIK), as opposed to T-cells and Natural Killer (NK) cells. The unique advantages of Formula's platform over existing autologous and viral-transfection based CAR approaches span across the CMC, regulatory and commercial spectrum. The CIK cells involved in Formula's CAR therapies have shown high therapeutic potency, WITHOUT the concommittant need for interleukins (e.g. IL-7, IL-12, IL-15). Formula's proprietary NON-viral gene transfection method leads to stable gene expression and offers efficient expansion and differentiation of the immune effector cells. Aside from offering desired therapeutic potency, the CIK cell-based CARs are believed to have a more favorable safety profile than T-cells, i.t.o. inducing cytokine storms and GvHD. CIK cells have demonstrated a longer in-vivo viability than NK cells. Complex purification processes, bead- or artificial cell facilitated optimization processes applicable to other CAR approaches can be circumvented with Formula's CMC process. Formula's CMC process and use of allogeneic CIK cells optimally facilitate scale up to commercial demand. Formula's use of the NON-viral vector based transfection method avoids the significant regulatory complexities that are associated with the viral vector based methods, which are typically used by other commercial developers of CAR based therapies. Lead indications initially involve different heme-oncology related targets.
Alliance & Collaborations
To be announced
Supporting Metrics or Evidence
Pre-clinical data package using Formula's CD123.CIK-CAR and CD19.CIK-CAR, along with clinical experience with unmanipulated CIK cells.
Current Financing Needs
To be discussed at conference
Current Timeline
GMP grade manufacturing process development ongoing. IND filing targeted within 12-18 months.
IP Status
Filed patents with broad and specific claims
Maurits Geerlings
CEO 

Foundation Fighting Blindness

The Foundation Fighting Blindness is a foundation founded in 1971 and headquartered in Colombia Maryland. The foundation typically makes allocations to companies in the range of $1-$8 million and is capable of providing $1-$15 over the investments lifetime. The firm does not look to take an equity position in companies but they do look for an ROI to return capital to the fund upon commercialization of the technology or change in ownership. The firm primarily funds companies located in the United States but will consider opportunities located globally as well. The firm provides equity capital and does look for a return though percentages taken are generally less than more financially motivated investors and all profits are reinvested back into the fund. Ideally the firm would like to allocate to 3-4 companies over the next 6-9 months.
Investor Type
Medtech Subsector
Biotech Phase of Development
Capital Structure Preference
Investment Stage Preference
Tom Capetan
Business Development 

Genrich

Genrich is a Multi-Family office founded and based in Long Beach California with additional offices in New York Toronto and London. The firm is looking to make equity and venture debt investments into companies in the life science space ranging from $2-$2 million over the lifetime of the investment often set up in tranches. Ideal candidates will be located 2 hours driving distance from one of the firm?s offices Boston and Chicago will also be considered. The firm is actively seeking new investment opportunities.
John Nelson
Managing Director 

Golden Seeds

Golden Seeds is an investment group that was founded in 25 and is headquartered in New York with other offices in Boston Silicon Valley and Texas. The group currently invests out of the Golden Seeds angel network and the Golden Seeds venture funds. The group has managed 3 venture funds that are Golden Seeds Fund LP Golden Seeds Fund 2 LP and Innovate New York LP Fund. The Golden Seeds angel network has 32 members of which 1 are life science investors. Golden Seeds invests in companies with a female founder or CEO or with women in other C-level positions or with at least 1% of equity owned by women. Golden Seeds prefers to invest in companies with a valuation under $5 million, the group?s first-round equity investments generally range from $ .25 million to $2 million. The group invests in companies based across the US and Canada.
Bill Whitaker
Managing Director Co-Chair Life Science Section 

H.I.G. BioVentures

H.I.G. BioVentures is the life science investment affiliate of H.I.G. Capital and has offices across the USA. H.I.G. BioVentures has assets under management of $4m and is investing from its second fund which closed at $268m in 212. The firm typically makes initial equity investments of $3-7m with the potential to invest up to $2m over the life of an investment. While most of H.I.G. BioVentures? portfolio companies are US-based the firm will consider opportunities worldwide.
Enoch Kariuki
Vice President 

Hercules Technology Growth Capital Inc.

Hercules Technology Growth Capital is a Private Equity company founded in 23 Headquartered in Palo Alto California with additional offices in Boston Boulder New York and McLean. The firm manages an evergreen structure and primarily provides high-growth companies in the life science space with senior secured debt financing. The firm can allocate up to $5 million per investment. The firm is very flexible with deal structures that can be customized to help companies reach their key milestones. The firm primarily invests in companies headquartered in the US but has the ability to invest overseas as well.
Janice Borque
Managing Director Life Sciences 

Horizon Technology Finance United States

Horizon Technology Finance is a venture lending, investment and financial services management company that was founded in 2003 and is headquartered in Farmington, Ct with additional offices in Walnut Creek, CA and Reston, VA. The firm controls approximately $200 million in assets under management and look to provide senior or subordinate loans to companies in the range of $2 to $20 million dollars, and often syndicates much larger deals. The firm prefers to lead or co-lead investments that they are involved in and looks to be involved in 15 deals in the next 6-9 months. The firm provides capital to companies located throughout the United States and Canada.

Year Founded
2003
Medtech Phase of Development
Capital Structure Preference
Investment Stage Preference
Jerry Michaud