Thrive Bioscience, Inc. United States

Thrive Bioscience is commercializing automated, analytical cell management laboratory instruments with integrated disposables. Thrive systems target the existing manual cell culture market ($8B), the cell-based assay market ($14B) and multi-billion dollar emerging markets for cell therapeutics. Thrive systems monitor, maintain, and passage cell lines, as well as run assays and generate large amounts of previously unavailable data.

Current methods of cell culture, developed more than 50 years ago, are now a major bottleneck holding back research and medicine, and cost society billions of dollars annually in waste and lost opportunity. Thrive Bioscience is the first company to wholly automate cell culture in research, diagnostic, and therapeutic markets.

Cell culture, especially the growth of human and other mammalian cells, is a fundamental tool used in science and medicine. As an example, the market for cell-based assays used in drug discovery accounts for $14B annually. One of the most rapidly growing and emerging segments requiring automated cell culture is the personal cell-based therapeutics market, for which human cells are genetically engineered, and then re-implanted into a patient.

Website:
thrivebio.com
Year Founded
2014
Main Sector
Medtech Subsector
Medtech Phase of Development
Current Financing Needs

Have raised $3M of a $4M round and seeking investors to complete the round.

Current Investors

Life Science Angels, Finney Capital and several seed investors.

Management Team Highlights

Management Team

·       CEO, Gary Paul Magnant -- Serial bio-tools entrepreneur; 3 prior successful exits; formerly Sage Science, MJ Research, ThermoCeramix, Owl Scientific

·       COO/CFO, Thomas Forest Farb -- Serial healthcare-centric entrepreneur; numerous successful exits and IPOs; formerly MedicaMetrix, Indevus Pharma, Interneuron Pharma, Cytyc

·       CSO, Alan Blanchard, PhD -- Numerous commercial instrumentation successes in DNA sequencing & DNA microarrays at Agencourt Personal Genomics and Lilly

·       VP Engineering & Manufacturing, Brian Foley -- Former Head of Technology & Engineering at Merck Millipore; numerous products developed and launched

Board of Directors

·       Guy Broadbent -- Former President of Laboratory Products Division of Thermo-Fisher Scientific; former CEO of XcellerX (acquired by GE Healthcare)

·        Michael Finney, PhD -- Managing Director of Finney Capital; former Co-Founder and CSO of MJ Research; Board Member of Sage Science

Tom Farb
Chief Operating Officer 

Twin Cities Angels Fund II, LLC United States

Twin Cities Angels is an angel group that was founded in 2006 that is based in Minnesota. The group has raised two funds that are The Twin Cities Angels Fund I and II. The second fund is currently looking to invest in emerging companies. The group typically provides seed and venture capital ranging from $ 25.000 to $2 million to life science companies. The group plans to invest in 4 to 6 companies per year. Twin Cities Angels seeks to invest in companies based in the Twin Cities Area of Minneapolis/St. Paul, the state of Minnesota and within a reasonable distance, such as Western Wisconsin, Northern Iowa, and Eastern Dakotas.

Year Founded
2006
Investor Type
Biotech Phase of Development
Medtech Phase of Development
Capital Structure Preference
Investment Stage Preference
John Alexander
Chairman & Founder 

Ventac Partners United States

Ventac Partners is a dedicated life science investment and consulting firm with offices in Europe, USA and Asia. Ventac Partners has a strong track record in founding new innovative companies, fund raising and supporting M&A transactions.

All partners are experienced and hands-on life science entrepreneurs with proven track-record in successfully starting, funding, growing and expanding international life science companies.

Neil Thomas
Neil Thomas
LinkedIn logo Partner 

Walter Greenblatt & Associates United States

Our clients are early-stage biotechnology, medical device, diagnostics and pharmaceutical service companies. When we begin working with a client they are frequently looking to complete proof-of-concept studies, secure intellectual property and other critical preliminary tasks. Typically we raise the first round ($1 - $5 million of capital) needed to accomplish these milestones, usually, but not always from angel investors. After key milestones have been achieved using that money, we generally follow by raising a second round of $5-20 million, usually institutional money, for development and growth

By working this way, we increase our clients' success rate raising capital and building their companies and the returns to the investors we bring into those companies. We have raised over $80 million in early stage funding for our clients (in Seed, Series A and Series B rounds) and delivered realized returns, so far, over $500 million—a realized return to date of over 6X—to the investors who provided that early stage capital, with a number of the companies still driving towards an exit that may increase that figure. Realized (cash-on-cash) internal rates of return for a hypothetical investor who participated in each round of financing offered by WG&A to date exceeds 65% annually.

Walter Greenblatt
Managing Director 

Wellington Partners Germany

Wellington Partners is a venture capital firm based in Munich, Germany, with an additional office in Zurich, Switzerland. The firm specializes in early-stage and growth capital investments in the Technology and Life Sciences sector. The firm has approximately €800M AUM and is currently investing out of a €100M fund for Life Science companies. Depending on the stage of the company, the firm can allocate up to €10M over the life of the investment. The firm can also lead or co-lead financing rounds of up to €30M or higher with syndicates. The firm focuses on European companies but will consider US-based companies with activities in Europe. The firm is actively seeking new investment opportunities.

Year Founded
1990
Biotech Phase of Development
Medtech Phase of Development
Capital Structure Preference
Investment Stage Preference
Rainer Strohmenger
General Partner 

Western Oncolytics, Ltd. United States

Western Oncolytics is developing a novel immunotherapy to treat a wide range of solid tumors.  Our therapy is an oncolytic vector with multiple therapeutic transgenes that both stimulate the immune system and remove local tumor immune inhibition.  The vector is engineered to avoid the immune system itself, thus overcoming a major drawback in competing designs.  It is the only therapy in the world with these leading attributes.  Western Oncolytics' therapy works in combination with other treatments, e.g. checkpoint inhibitors, and is capable of systemic (intravenous) delivery. 

Our team comprises the leading scientists, clinicians, and regulatory experts within our field, including entrepreneurs who successfully exited companies with earlier technologies.  In comparison animal testing measuring tumor growth and survival, our therapy performed far better than earlier, clinically-proven oncolytic therapies.

Western Oncolytics is currently raising investment to complete preclinical development and a planned clinical trial. 

Year Founded
2013
Biotech Phase of Development
Technology Overview
Immunotherapy, Oncolyics for Cancer
Supporting Metrics or Evidence
Comparative Live Animal Data
Current Investors
Private
IP Status
PCT Application
Recent Milestones
Seed Funding Round Completed
Management Team Highlights
Experienced Regulatory, Scientific, Medical and Development Experts within our Field
Kurt Rote
CEO 
BIO

Graduated from Duke in three years while studying Biomedical Engineering and working part-time. Hands-on lab experience using viral vectors to deliver genes to cells. MBA from IMD, a one year program in Lausanne, Switzerland. International network and experience including strategy, business development, project management, product development and start-ups.

WuXi Venture Fund United States

WuXi Venture Fund is the corporate venture arm of WuXi AppTec, a multinational CRO based in Shanghai China with multiple offices across China and the United States. The fund makes equity investments into technology and life science companies to enhance or leverage WuXi AppTec's platform capabilities. The investment size will be varied based on a case-by-case basis. The firm invests in life science companies across the globe with an emphasis in China and the US.

Alexis Ji
Principal 
Sofie Qiao
Managing Director 

Xalud Therapeutics, Inc. United States

Xalud Therapeutics is developing novel, non-opioid therapies for the treatment of neuropathic pain and osteoarthritis. Our lead product, XT-101, has shown exceptional efficacy in the leading rodent models of pain and in canine patients with neuropathic pain and osteoarthritis. XT-101 has an excellent safety profile -- it does not cause sedation, dizziness, numbness, addiction or tolerance.  7 and 28 day GLP toxicology studies have been completed with excellent results.  Xalud intends to file an IND for a Phase I/IIa trial in mid-2015 and, pending funding, initiate clinical trials thereafter.

Xalud's approach to treating pain is fundamentally different than conventional approaches. XT-101 causes the body to produce the natural anti-inflammatory IL-10.  In neuropathic pain, the use of this broad spectrum anti-inflammatory reduces inflammation around the spinal cord and reduces aberant pain signaling.  In gold-standard rodent models, a single injection of XT-101 completely eliminates neuropathic pain for 12 weeks.  We have also tested XT-101 in canine patients with severe osteoarthritis that has been resistant to standard treatments.  In these patients, XT-101 has provided long lasting pain relief resulting in dramatically increased mobility and activity levels and increased joint flexibility.

To date, Xalud's efforts have been supported by over $6 million of grant funding from the NIH, the DOD, and disease foundations.  We seek to raise $6 to $10 Million to fund our initial clinical trial or trials.  These will be placebo controlled Phase I/IIa trials in actual patients.  Because XT-101 has an extended duration, we expect that these trials will provide the safety, efficacy and biomarker data necessary to support a robust Phase II program.

Year Founded
2009
Biotech Phase of Development
Technology Overview
XT-101 is a proprietary plasmid DNA encoding for the natural, broad spectrum anti-inflammatory IL-10
Alliance & Collaborations
Xalud has received extensive support from the NIH and the DOD
Supporting Metrics or Evidence
In leading models of pain, a single administration completely reverses neuropathic pain for 12 weeks. Similar results have been observed in canine patients with osteoarthritis and neuropathic pain.
Current Financing Needs
$6MM to $10MM
Current Timeline
An IND for a Phase I/IIa trial will be filed in mid-2015.
Current Investors
Xalud is entirely grant funded and has raised over $6 MM in non-dilutive financing.
IP Status
Broad patent coverage and freedom to operate have been established
Recent Milestones
In late 2014, 7 and 28 day GLP toxicology studies were completed with excellent results.
Management Team Highlights
The Management team has substantial experience leading early stage biotech companies. Dr. Steve Collins, Xalud's Executive Chairman, has extensive experience managing biopharmaceutical companies and leading pain and CNS drug development efforts. He served as Senior Director for Global CNS and Pain at Johnson and Johnson and Chief Scientific Officer and Vice President of Medical Affairs at Ovation Pharmaceuticals (acquired by Lundbeck for approximately $963 MM). Most recently he served as Chief Executive Officer of NeuroTherapeutics Pharma, Inc., a venture-backed biotechnology company developing treatments for pain and epilepsy.
Peter Heinecke
Chief Business Officer