MidCap Financial LLC

MidCap Financial is a commercial finance firm that was founded in 28 with offices in Bethesda MD Chicago IL and Los Angeles CA. The firm focuses on providing debt financing solutions to healthcare companies. The firm generally provides loans of around $15 million and is involved in approximately 15 new deals each year. The firm considers companies located around globe.
Josh Groman
Managing Director 
James Taylor
Director 

MP Healthcare Venture Management, Inc. United States

MP Healthcare Ventures is the corporate venture arm of Mitsubishi Tanabe Pharma founded in 2006 and based in Boston Massachusetts. The firm is looking to provide equity capital to seed and venture stage companies in the life science space. The firm is looking to provide companies with $5 million over the lifetime of the investment and plans on making 2-3 investments over the next year. The firm will invest in companies located anywhere around the world.

Tetsuro Iwata
Senior Manager 

N8 Medical United States

N8 Medical is a development-stage medical device company focused upon commercializing antimicrobial medical devices and coatings to address the multibillion dollar public health and economic burden associated with medical device-related hospital acquired infections and healthcare associated infections (HAIs).  N8 Medical’s key differentiator from competitors is the application of a novel, proprietary class of pharmaceutically active compounds known as ceragenins, Cationic Selective Antimicrobials, or CSAs (ceragenins or CSAs) to medical devices for the purpose of providing antifouling or anti-infective properties. N8 Medical believes that ceragenins offer unparalleled efficacy and cost advantages over other coatings and means of addressing HAIs. Further, the use of ceragenins as a platform technology under its CONTEGO™ brand across numerous device segments with multiple coating options provides N8 Medical with a unique, sustainable competitive advantage over other medical device companies.  

N8 Medical is seeking $6 million in investment capital, which it believes will be sufficient to fund development, FDA approval and CE Marking of its proprietary coated CONTEGO™ endotracheal tube (ETT), and initial commercialization activities. N8 Medical has designed its antimicrobial ETT to reduce ICU stays by a single day or more, thereby saving the hospital $3,000 to $5,000 in non-reimbursable costs per ICU patient, and, significantly, by freeing up an ICU bed one day earlier for a new revenue-generating patient and resulting in better profitability for providers and substantial opportunity cost savings.  Thus, N8’s CONTEGO™ ETT presents a compelling value proposition for hospitals.  N8's internal valuation model aligns with relevant market data and comparable companies, indicating a successful antimicrobial device company could achieve a value of over $100 million.  

 

Year Founded
2010
Biotech Subsector
Biotech Phase of Development
Medtech Phase of Development
Technology Overview
Novel antimicrobial small molecule mimetics of antimicrobial peptides applied to medical devices
Alliance & Collaborations
Engaged with leading medical device companies for technology feasibility evaluations
Supporting Metrics or Evidence
in vitro and in vivo efficacy and safety studies
Current Financing Needs
$6 million
Current Timeline
Clinical study planned for Q4 2015/ Q1 2016
IP Status
Patent protection into the 2030's
Management Team Highlights
Successful track record medical technology commercialization, including an IPO
Carl Genberg
CTO 
Michael Triplett
Michael Triplett
CEO 

Naegis Pharmaceuticals Inc. Canada

Naegis, based in Vancouver, British Columbia, is developing novel, small-molecule leukotirene synthesis inhibitors (LTSIs) for serious inflammatory conditions.  The Company is currently focused on two proprietary programs: 

topical and oral therapy for Uveitis, a condition that is responsible for 10% of legal blindness in the US and for which there are limited therapeutic options. 

o oral therapy for Chronic Obstructive Pulmonary Disease (COPD),  a serious lung disease with increasing rates of mortality.

Naegis has developed a large library of LTSIs that are potent inhibitors of either 5-LO or LTA4H.  The Company is currently identifying a lead compound for selection for futher development for ocular disease, in particular Uveitis.

The Company is also advancing a series of compounds that are novel structures and highly selective and potent inhibitors of LTA4H, which are expected to be developed as new therpaies for COPD

Naegis is seeking pharmaceutical partners and capital investment to advance more rapidly their novel programs.

Year Founded
2010
Biotech Subsector
Biotech Phase of Development
Technology Overview
Leukotrienes are key inflammatory mediators implicated in many diseases. There is growing evidence of their central role in Uveitis. 5-LO inhibitors have been shown to reduce the clinical signs of uveitis in animal models. Naegis is developing potent 5-LO inhibitors that are both topically and orally active, with unique structures that are not expected to have the limitations of earlier 5-LO inhibitors. In COPD recent evidence has demonstrated the critical role for LTA4H in the progression and persistence of the disease. However it has recently been shown that LTA4H has a dual role and functions as both a pro and anti-inflammatory. Thus it is necessary to identify compounds that are active only against the pro-inflammatory function of the enzyme, whilst sparing its anti-inflammatory effects. Naegis is developing highly specific inhibitors of LTA4H that inhibit only the anti-inflammatory activity of LTA4H.
Alliance & Collaborations
In discussion
Current Financing Needs
$500,000 - $1,000,000
Current Timeline
Lead
Current Investors
Private.
IP Status
Proprietary compounds
Management Team Highlights
CEO - Dr. David Burgoyne an experienced medicinal chemist who has developed compounds that are in current human clinical trials. Also on the Board are Dr. Philip Davies, formerly Executive Director of Research and Area Head of Immunology at Merck, New Jersey. Also Dr Julia Levy, founder of QLT and developer of the first effective therapy for macular degeneration.
Ian McBeath
Ian McBeath
Corporate Development 

National Heart Lung and Blood Institute

The Office of Translational Alliances and Coordination (OTAC) at the National Heart, Lung, and Blood Institute supports the development of innovative biomedical products to address unmet medical needs in the heart, lung, blood and sleep fields.  OTAC is home to the NHLBI's small business programs (SBIR and STTR) and the NIH Centers for Accelerated Innovations.

The NHLBI's SBIR and STTR programs comprise one of the largest sources of early-stage capital for U.S. small business, acting as engines of innovation for developing and commercializing novel technologies and products that aid in the prevention, diagnosis, and treatment of heart, lung, blood, and sleep diseases and disorders. The NHLBI provides grant and contract funding opportunities and resources to support small businesses performing research and development on technologies related to the mission of NHLBI. With an annual budget of $85M, the NHLBI funds about 200 companies each year through the Institute's small business programs.

The NIH Centers for Accelerated Innovations accelerate translation of scientific discovery into commercial products that improve health for patients. This unique public-private partnership is changing the way discoveries with scientific and commercial potential are identified and developed.

Dr Kurt Marek
Dr Kurt Marek
LinkedIn logo Deputy Director OTAC 
Dr Gary Robinson
Dr Gary Robinson
LinkedIn logo Business Development Specialist 

New Leaf Venture Partners

New Leaf Venture Partners is a venture capital company formed in 25 with offices in New York and San Mateo California. The firm currently manages two funds with its most recent fund having closed at $45 million in 27. The firm is looking to make equity investments ranging from $1-$25 million over the lifetime of the investment. The firm looks for companies primarily in the United States and some select opportunities in Europe. The firm plans to make between 1-5 investments over the next year.
Mike Dybbs
Principal 
Sunil Shah
Partner 
Prashant Shah
Partner 

Pappas Ventures

Pappas Ventures is a Venture Capital company based in Durham North Carolina founded in 1994. The firm manages 4 funds for a total of approximately $35 million in assets under management. The firms is currently investing out of its $1 million 4th fund focused exclusively on the life sciences. The firm looks to provide up to $5 million of preferred equity capital in the initial round and up to $1 million over the life of the investment. The firm is very flexible in terms of period to exit but generally looks to exit in around 5 years. The firm plans to make 2-3 investments over the next 6-9 months and will consider companies throughout North America.
Jayson Punwani
Associate 

PBM Capital Group

PBM Capital is a hybrid family office and operating company based in Charlottesville Virginia with an additional office in New York City. The firm is funded and led by the successful life science entrepreneur Paul Manning who started and sold several companies in his career. The firm can make investments ranging from approximately $5 to $1 million into companies and due to its funding structure has no requirements for holding period or capital structure. The firm makes investments in the forms of equity controlling interest in-licensing MBO/LBO growth capital and is also willing to co-invest. The firm is looking for companies located around the globe and makes around 5-15 investments in a given year.
Jayson Rieger
SVP of Business Development & Portfolio Management 

Pfizer Venture Investments United States

Pfizer Venture Investments (PVI) is the corporate venture capital arm of Pfizer and was founded in 2004. PVI has an annual investments budget of $50 million and invests up to $10M per investing round. The firm focuses mainly on U.S. startups but has global reach. PVI attempts to allocate 80% of its funding to U.S. based companies and utilizes the remaining 20% for international ventures. PVI provides equity funding for private companies in need of seed, growth, or venture financing. Remaining opportunistic, PVI focuses entirely on high growth prospects in all sectors and all phases of development. The ideal candidate has a potential for high growth and returns. Additionally, PVI will seek to in-license products and buyout companies if the opportunity arises.

Barbara Dalton
Vice President