Formula Pharma United States

Formula Pharmaceuticals is a US-based oncology focused biotech company, developing Chimeric Antigen Receptor (CAR) based therapies using a proprietary platform.

Formula's CAR therapies involve allogeneic immune effector cells and a NON-viral transfection method for highly efficient cell expansion and differentiation. Additionally, Formula's target effector cells primarily involve Cytokine Induced Killer cells, instead of T-cells or Natural Killer cells. These various characteristics offer distinct practical, clinical, regulatory and commercial benefits over other CAR approaches that involve autologous cells and viral transfection methods. Although not yet in clinical stage development, Formula believes that its CAR based development program will catch up with competing clinical-stage development programs, based on the significant CMC and regulatory advantages that Formula's CAR approach offers.

Formula is interested in meeting with investors and prospective pharmaceutical/biotech partners. Near-term value driving milestones (including clinical trial results) are expected within the next 2-3 years.

Significant industry and investor interest in CAR based therapies have been established over the past 12 months, with 4 leading industry players (Pfizer; Novartis; Celgene and Juno Therapeutics). Formula's CAR therapy is distinctive, and is believed to offer significant advantages of the aforementioned CAR technologies. CARs represent a new and important paradigm for cancer therapy, with the leading pharmaceutical players expected to acquire and develop their own position into this space.

Year Founded
2009
Biotech Subsector
Biotech Phase of Development
Technology Overview
Formula's lead program involves a distinctive approach for the development of Chimeric Antigen Receptor (CAR) based therapies. Formula's proprietary platform involves allogeneic immune cells and NON-viral transfection for the develoment of CAR therapies, using primarily Cytokine Induced Cells (CIK), as opposed to T-cells and Natural Killer (NK) cells. The unique advantages of Formula's platform over existing autologous and viral-transfection based CAR approaches span across the CMC, regulatory and commercial spectrum. The CIK cells involved in Formula's CAR therapies have shown high therapeutic potency, WITHOUT the concommittant need for interleukins (e.g. IL-7, IL-12, IL-15). Formula's proprietary NON-viral gene transfection method leads to stable gene expression and offers efficient expansion and differentiation of the immune effector cells. Aside from offering desired therapeutic potency, the CIK cell-based CARs are believed to have a more favorable safety profile than T-cells, i.t.o. inducing cytokine storms and GvHD. CIK cells have demonstrated a longer in-vivo viability than NK cells. Complex purification processes, bead- or artificial cell facilitated optimization processes applicable to other CAR approaches can be circumvented with Formula's CMC process. Formula's CMC process and use of allogeneic CIK cells optimally facilitate scale up to commercial demand. Formula's use of the NON-viral vector based transfection method avoids the significant regulatory complexities that are associated with the viral vector based methods, which are typically used by other commercial developers of CAR based therapies. Lead indications initially involve different heme-oncology related targets.
Alliance & Collaborations
To be announced
Supporting Metrics or Evidence
Pre-clinical data package using Formula's CD123.CIK-CAR and CD19.CIK-CAR, along with clinical experience with unmanipulated CIK cells.
Current Financing Needs
To be discussed at conference
Current Timeline
GMP grade manufacturing process development ongoing. IND filing targeted within 12-18 months.
IP Status
Filed patents with broad and specific claims
Maurits Geerlings
CEO 

Foundation Fighting Blindness

The Foundation Fighting Blindness is a foundation founded in 1971 and headquartered in Colombia Maryland. The foundation typically makes allocations to companies in the range of $1-$8 million and is capable of providing $1-$15 over the investments lifetime. The firm does not look to take an equity position in companies but they do look for an ROI to return capital to the fund upon commercialization of the technology or change in ownership. The firm primarily funds companies located in the United States but will consider opportunities located globally as well. The firm provides equity capital and does look for a return though percentages taken are generally less than more financially motivated investors and all profits are reinvested back into the fund. Ideally the firm would like to allocate to 3-4 companies over the next 6-9 months.
Investor Type
Medtech Subsector
Biotech Phase of Development
Capital Structure Preference
Investment Stage Preference
Tom Capetan
Business Development 

Golden Seeds

Golden Seeds is an investment group that was founded in 25 and is headquartered in New York with other offices in Boston Silicon Valley and Texas. The group currently invests out of the Golden Seeds angel network and the Golden Seeds venture funds. The group has managed 3 venture funds that are Golden Seeds Fund LP Golden Seeds Fund 2 LP and Innovate New York LP Fund. The Golden Seeds angel network has 32 members of which 1 are life science investors. Golden Seeds invests in companies with a female founder or CEO or with women in other C-level positions or with at least 1% of equity owned by women. Golden Seeds prefers to invest in companies with a valuation under $5 million, the group?s first-round equity investments generally range from $ .25 million to $2 million. The group invests in companies based across the US and Canada.
Bill Whitaker
Managing Director Co-Chair Life Science Section 

Gordian Biotechnologies Inc. United States

Gordian Biotechnologies addressing the urgent unmet medical existing within antibiotic resistance by developing first-in-class reversible b-lactamase inhibitors that allow existing antibiotics to be effective against otherwise resistant pathogens. By combining an FDA approved antibiotic with our novel b-lactamase inhibitors, Gordian Biotechnologies  disarms the bacteria’s resistance mechanism, allowing the antibiotic to defeat the pathogen. 

Biotech Subsector
Biotech Phase of Development
Technology Overview
Reversible beta-lactamase inhibitor
Current Financing Needs
Seeking lead investor for our $1M round
Mr Tony Brazzale
Mr Tony Brazzale
LinkedIn logo President & CEO 

Greenhouse Capital Partners United States

Greenhouse Capital Partner is a venture capital firm that was founded in 2006 and is based in Sausalito, California. The firm selectively makes equity investments into life science companies in seed stage and series A financing round, but it also provides growth equity to highly capital efficient companies that can achieve cash flow break-even within two years. The typical investment size ranges from $0.25 million to $2 million.The firm focuses on investments in US based companies.

Eric Desai
Principal 

Horizon Technology Finance United States

Horizon Technology Finance is a venture lending, investment and financial services management company that was founded in 2003 and is headquartered in Farmington, Ct with additional offices in Walnut Creek, CA and Reston, VA. The firm controls approximately $200 million in assets under management and look to provide senior or subordinate loans to companies in the range of $2 to $20 million dollars, and often syndicates much larger deals. The firm prefers to lead or co-lead investments that they are involved in and looks to be involved in 15 deals in the next 6-9 months. The firm provides capital to companies located throughout the United States and Canada.

Year Founded
2003
Medtech Phase of Development
Capital Structure Preference
Investment Stage Preference
Jerry Michaud

Humabs BioMed SA Switzerland

Humabs BioMed is a profitable Swiss biotech company that is discovering and developing nature-selected human monoclonal antibodies using proprietary platforms. 

Humabs is currently focusing on the development of human antibodies to fight infectious diseases. Additional indications are being targeted at the discovery research stage.

Humabs has already achieved four major licensing deals with Pharmaceutical companies generating significant revenues in the form of near term revenues, as well as a stream of longer term milestones and royalties. Two of these programs are in clinical development phases.

Humabs is seeking additional investments to allow the company to bring selected programs into clinical research on its own, thus significantly increasing the added value.

Website:
www.humabs.com
Year Founded
2010
Biotech Subsector
Biotech Phase of Development
Technology Overview
Unique technology platform and know how allowing selection of monoclonal antibodies generated from immortalized human memory B cells, plasma cells or naïve B cells. Specialized in identifying, isolating, characterizing and producing the best fully human antibodies from the best human responders (antibodies of winners). Focused on infectious diseases, in which there is an acute need for new products. Additional indications include inflammatory diseases and cancer.
Alliance & Collaborations
With global Pharma companies
Current Financing Needs
Humabs is seeking additional investments to allow the company to bring selected programs forward to the more advanced drug development stages of clinical research, thus significantly increasing the added value.
Current Investors
Private
IP Status
Granted patents on technology and granted patents + applications on mAb products
Dr Alcide Barberis
Dr Alcide Barberis
LinkedIn logo President & CEO 

Iliad Ventures

Iliad Ventures is a private investment firm funded entirely by its partners that is based in New York City. The firm is looking to make equity investment into early and mid-stage life science companies ranging from $5 to 2 million initially. The firm looks to get involved in Seed and Series A Rounds. The firm could make as many as 6 investments over the next 12 months and looks to invest in companies located throughout the United States Europe and Israel.
Steve Tsetsekos
General Partner 

Immunova LLC United States

Immunova is a startup with  an IP portfolio licensed from Yale and the Johns Hopkins Universities.

Immunova's technology platform has a unique capability to deliver one or more drugs to the tumor/disease microenvironment. The drugs can be proteins, small molecules or nucleic acids. The delivery platfrom has demonstatable advantages over other delivery systems. The technology has applications in oncology and inflammation.

The company's lead asset is positioned in oncology. IMM-01, consists of two drugs that (a) undermine the tumor micorenvironment and (b) increase anti-tumor cell mediated immunity. This asset is capable of curing mice of metastatic disease. Further, it significantly enhances the activites of immune checkpoint inhibitors. It is non toxic.

The company is seeking investment and R&D partners. Immunova has defined the path to a Phase I/IIa multidose trial which could initiate within 15 months of funding. Immunova is also seeking partners who wish to validate this platform in oncology and inflammation.

Website:
www.immunova.net
Year Founded
2011
Biotech Subsector
Biotech Phase of Development
Technology Overview
Immunova’s platform enables effective drug combination therapy. Chemically diverse drugs such as biologics and small molecules can be formulated and encapsulated in a liposome and thereby delivered systemically to a target cell or environment where each encapsulated API can be released independently in a controlled or tuneable manner using our proprietary technology. Importantly, this approach also potentiates existing or novel therapies often increasing their therapeutic index. LipoGel-TR is a hybrid platform of liposomes and PLGA nanoparticle delivery systems designed to possess the positive features of each platform while minimizing the negative aspects. Many of the building blocks required to make a LipoGel can be bought preassembled and GMP from third party providers thus shortening development timelines. We have demonstrated the superiority of LipoGels in numerous in vitro assays (drug loading and release and potency) and animal models of disease (efficacy and survival). Using our technology we have demonstrated that we can (a) direct one or more drugs to the TME, (b) increase drug synergies, efficacy and potency of chemo and immunotherapies, (c) decrease drug toxicity, (d) increase immune cell activity and (e) generate new intellectual property.
Alliance & Collaborations
The company is actively seeking partners in oncology and inflammation.
Supporting Metrics or Evidence
The technology has been published in high profile journals and the founder actively collaborates with numerous scientists at leading institutions. The Company’s initial focus is cancer immunotherapy: delivery of molecules that modulate immunity, positively and negatively, in order to undermine the tumor microenvironment and allow the immune system to keep pace with tumor evolution and thus be primed to eradicate disease. Our lead asset, IMM01: • Is targeted to and accumulates in tumors; • Encapsulated APIs are slowly released over 7 days and this can be further modulated; • Dramatically increases potency and efficacy: in a murine model of metastatic disease, IV delivery of IMM-01 results in 85% survival of IMM-01-treated mice at day 60 whereas all untreated mice, as well as mice treated with the drugs in solution, have died by day 30; • Increases immune infiltrate within the tumor which correlates with good patient outcomes • Significantly increases the potency of anti-PD1 and anti-CTLA4 mAb therapy in a mouse model of metastatic disease supporting published MoA studies • Is not toxic; there are no signs of renal, hepatic, bronchial, RBC or leukocyte toxicity when IMM-01 is administered to mice at high doses.
Current Financing Needs
Immunova is seeking $8-10M to fund operations for three years and including a phase I/IIa clinical trial
Current Timeline
Pending financing, IMM-01 is ca 15 months from a Phase I/IIa clinical trial
Current Investors
Angel-backed to date
IP Status
The company has licensed 4 granted and 3 pending patents
Recent Milestones
Q3 2014 • Demonstration of synergy with checkpoint inhibitors • New patent filed • Patent granted • Academic founder noted as a bioentrepreneur to watch by Nature Biotechnology Q4 2014 • First phase technology transfer to CMO • Identified lead clinical trial site and PI • Determined drug needs for clinical trial • Regulator engaged for ‘preIND meeting’
Management Team Highlights
The Company has recruited an impressive team that has an established and successful record of building companies. The management, advisors and scientific founders have an established network of both pharmaceutical and medical contacts and extensive experience running biotechnology firms and executing clinical trials. For reference, the following biotech startups founded/managed/invested in by Immunova Management or Advisors, were acquired prior to FDA approval: • Neurovir Therapeutics, Inc. – Acquired by MediGene AG for $42M • Nurel Therapeutics – acquired by DyaMid AB (undisclosed) • Proximagen plc. – Acquired by Upsher Smith for $550M • PharmaGenics Inc. – acquired by Genzyme for $28M • Prostagen– acquired by Cytogen (undisclosed)
Brian Horsburgh

Immusoft Corporation United States

Immusoft’s mission is to develop a breakthrough platform for delivering targeted medicines — programming a patient’s own cells to become miniature drug factories.

Our technology instructs a patient's cells to constantly secrete gene-encoded medicines (biologics). It will enable new treatments by solving current delivery limitations and production challenges. We are initially targeting orphaned diseases. 

Immusoft’s platform can program cells to continually produce and secrete therapeutic proteins and rare antibodies that have been impossible to elicit with a vaccine. This approach makes possible treatments that are otherwise impractical due to short halflife, injection site reactions, production challenges or a small market size. It offers many of the benefits of traditional approaches and modern gene therapies with less risk and greater control.

Immusoft has received grants from the National Institutes of Health and Peter Thiel's Breakout Labs as well as support from private investors, including the former head of preclinical development at Seattle Genetics. We have an exclusive license option on our core technology from Caltech and have filed two additional patents covering our extensive modifications to the technology.

ISP technology could replace a lifetime of infusions with a patient’s own drug-producing cells.

Website:
www.immusoft.com
Year Founded
2009
Biotech Phase of Development
Technology Overview
Turning patients' cells into drug factories
Alliance & Collaborations
Fred Hutchinson Cancer Research Center, Discovery Genomics, Inc, University of Minnesota, The Ragon Institute, University of California San Francisco
Supporting Metrics or Evidence
Late-stage preclinical
Current Financing Needs
$3 to >$20M
Current Timeline
Preparing IND for clinical trial
Current Investors
Breakout Labs, Founders Fund Science, several angels
IP Status
multiple patents filed worldwide
Recent Milestones
GMP scale-up in preparation for clinical trial; engaging the FDA for Investigator-initiated IND; use of Sleeping Beauty Transposon non-viral vector
Management Team Highlights
Matthew Scholz (Founder and CEO) – Seasoned startup executive; founded and exited Point B Telematics. Eric Herbig, Ph.D., M.B.A. (CSO) – 15+ years of research experience and significant commercialization and management expertise. Zach Hall (Dir. of Operations) – Co-founder and operations director at two previous biomedical startups. Mei Xu, Ph.D. (Dir. of Research) – Molecular biologist with extensive research experience.
J. Zach Hall
Director of Operations 
Matthew Scholz
CEO