Bioarray Therapeutics Inc. United States

BIOARRAY is a biotech company located at the Science park in New Haven. BIOARRAY is customizing treatments for patients to cure breast cancer the first time. BIOARRAY’s lead breast cancer test has been shown to reduce ineffective treatments by over 50% in proof of concept studies. BIOARRAY is a recipient of Avon Foundation and Connecticut Innovations funds. BIOARRAY is a MassChallenge Accelerator Winner.

Biotech Subsector
Biotech Phase of Development
Technology Overview

In contrast to most studies that focus on the unhealthy cancer patient populations, BIOARRAY studies cancer in reverse by using genes in healthy cell organization to identify cancer markers. These biomarkers work like surveillance cameras watching how a particular breast cancer will behave when treated with chemotherapy. By measuring the mRNA expression levels of these biomarkers, Bioarray diagnostic tests significantly increase the accuracy of predicted chemo-response rates.

Alliance & Collaborations
Avon Foundation, Connecticut Innovations
Supporting Metrics or Evidence

BIOARRAY's lead test distinguishes itself by addressing a vital question at the beginning of basic chemotherapeutic treatment for 75% of diagnosed breast cancer patients who currently have a 24% response rate. BIOARRAY's test clinical proof of concept studies showed:

55% reduction in ineffective chemo

68% improvement in response rate

42% of patients classified as non-responders up front

Current Financing Needs

The company is raising its Series A round of financing to achieve key milestones to take the lead test to early adoption.

Current Timeline

BIOARRAY has developed a business plan whereas the Bioarray diagnostic uses commercially-available gene-expression platforms such as PCR for its lab analysis. BIOARRAY will engage licensees and distributors to access the global market. BIOARRAY will hold closely the proprietary algorithms at the heart of the diagnostic in a cloud-based information platform. BIOARRAY's lead test is in a position to go to market within 2 years.

Current Investors

Grant: Avon Foundation – first of its kind from Avon

Equity: Connecticut Innovations and Angels

IP Status

BIOARRAY intellectual property includes methods, algorithms and biomarkers. BIOARRAY strategy to protect its intellectual property is a combination of trade secrets and patents. The company is growing a patent portfolio of US and international patents that is exclusively owned by BIOARRAY and is not subject to licensing or royalty obligations.

Recent Milestones

  1. Performed clinical proof of concept with I-SPY 1 clinical trial
  2. Data gathered (and ready to complete analysis) for I-SPY 2 trial
  3. Built cloud-based interactive information platform and interactive portal
  4. Built laboratory infrastructure
  5. Developed IP strategy comprising know-how and patents (internationally filed)
Management Team Highlights

CEO Marcia Fournier has over a decade of experience in oncology at leading Institutions in the US. Non-executive chairman Michal Preminger and Board Directors Una Ryan and Henry Kay have extensive experience in management, financing, acquisitions, and diagnostics. The Company also has a team of active business advisors with experience in business development, acquisitions and venture capital.

Marcia Fournier
Marcia Fournier
LinkedIn logo CEO 
BIO

Marcia, a molecular biologist, came to the United States from Brazil about 15 years ago. Marcia is trained in genetics with 10+ years of experience in cancer research. She most recently held a position at GlaxoSmithKline, Oncology Center of Excellence for Drug Discovery. Marcia’s work as a doctoral fellow at the Dana-Farber Institute and postdoctoral fellow at UC Berkeley led to seminal publications on biomarker discovery.

Rana Gupta
Rana Gupta
LinkedIn logo Business Advisor 
BIO

Rana K, Gupta is trained as a businessman (not a techie), Rana has worked in several industries (pharma, consulting, VC), but he comes to BIOARRAY as a result of having invested in, run, and ultimately sold diagnostic company HistoRx to Novartis.

 

BioFocus, A Charles River Company

Charles River discovery offers a truly integrated approach to small molecule drug discovery, uniting all of the key disciplines required to achieve a program's goals in a single project team. With the acquisition of BioFocus, Argenta and Chantest, the CRL Discovery organization can integrate medicinal chemistry, physical sciences, CADD, in vitro biology, HTS, structural biology, ADMET/PK and disease models as required.

Website:
www.criver.com
Service Provider Type
Biotech Subsector
Unique Capabilities

Fully integrated services including:

Target Discovery

Complex in vitro Biology

HTS

Structural Biology

Medicinal Chemistry and CADD

Integrated Drug Discovery

Pharmaceutical Sciences

ADME/PK

In vivo services

Barbara Carlilse
Director Business Development 

Bionic Vision Technologies Australia

Bionic Vision Technologies is the commercial entity which holds license to the patents around technology developed by Bionic Vision Australia.

Bionic Vision Australia brings together Australia’s leading experts in medical bionics to develop a bionic eye to restore vision to people with retinitis pigmentosa and age-related macular degeneration.  A prototype device has been successfully implanted into three patients for two years demonstrating outstanding safety and efficacy. 

Our capabilities which  differentiate us from competitors include:

  1. Novel surgical techniques providing greater safety and stability od wide view devices

  2. World leading, pioneering vision processing software

  3. Unique arrangement and stimulation strategies of the electrodes

  4. Unique diamond electrode encapsulation for the high acuity device

  5. World leading psychophysics laboratory for assessing functionality of the devices

  6. Unprecedented expertise and proven track record in preclinical studies

Our development portfolio consists of  wide view devices which aim to increase mobility and independence of patients and a high acuity device which will allow patients the ability to read large letters and recognise faces

Year Founded
2011
Main Sector
Medtech Phase of Development
IP Status
7 granted patents, 45 patent applications
Recent Milestones
Completed successful pilot clinical trial
Julia Hill

Bionure Inc. United States

Bionure is a late-preclinical company focused at developing First-in-Class SGK agonists for the treatment of orphan ophthalmological diseases.

Bionure's main candidate is BN201, a small molecule, new chemical entity, first-in-class drug that promotes neuroprotection and remyelination by means of a novel MOA.

Our main therapeutic focus is Optic Neuritis (ON), an acute, inflammatory disease of the optic nerve that qualifies for orphan status. BN201 has been granted orphan designation for the treatment of ON and the patent has been granted.

Preclinical efficacy studies have been performed in several animal models and a pre-IND meeting has been held with the FDA to validate our preclinical and clinical development. 

BN201 is now through the regulatory toxicology studies to enable IND by Q2 2015.

Website:
www.bionure.com
Year Founded
2009
Biotech Subsector
Biotech Phase of Development
IP Status
Patent has been granted
Recent Milestones
Orphan designation for the treatment of Optic Neuritis
Albert Zamora
Managing Partner CEO 

BioPacific Investor, Inc.

Ann Gaddy
Managing Director 

BioScience Managers Australia

BioScience Managers is a venture capital life science investment firm headquartered in Melbourne, Australia. The group makes equity investments from $3M-5M and anticipates about 6 new investments this year. BioScience Managers invests globally. 

BioScience Managers will invest in companies across the life science space, including therapeutics, diagnostics and medical technology. The group does not invest in service providers. BioScience Managers considers all subsectors and indications, including orphan indications. The group will consider technology either in or prepared for human clinical trials and is open to all classes of devices. BioScience Managers seeks investments in novel technology and is not looking to gain share of an existing market. 

Investor Type
Biotech Phase of Development
Medtech Phase of Development
Capital Structure Preference
Investment Stage Preference
Jeremy Curnock Cook
Managing Director 
Amanda Gillon
Investment Analyst 
Matt McNamara
CIO 

Biosight, LLC and MIT United States

Biosight, LLC  is a start-up biomedical device company developing a low-cost technology that will enable health care providers (HCPs) to discriminate amongst different types of tissues so that they will no longer need to use the blind and semi-blind approach to procedural instrument placement. The key intellectual capital of Biosight, LLC, (Biosight) is medical procedure needle tip tissue identification using multimodal spectroscopy (MMS) technologies first developed in the Laser Biomedical Research Center (LBRC) at the Massachusetts Institute of Technology. Several founding members of Biosight are the pioneers in this field and have established collaborations with clinicians at the Massachusetts General Hospital to identify clinical areas for this technology. Currently, Biosight, LLC is working with several investors in Massachusetts to further develop the device for numerous clinical applications

Year Founded
2014
Main Sector
Biotech Subsector
Biotech Phase of Development
Medtech Phase of Development
Alliance & Collaborations
Massachusetts Institute of Technology and Massachusetts General Hospital
Current Financing Needs
$10M
IP Status
Application Filed
Recent Milestones
Finalist in MIT 100K Pitch 2014
Management Team Highlights
Harvard and MIT Collaborators
Cheryl Campbell
Cheryl Campbell
LinkedIn logo MIT MBA Student and Intellectual Property Attorney 
BIO

A cancer scientist, corporate/IP lawyer and MBA candidate at the MIT Sloan School of Management who is dedicated to commercializing innovative biopharmaceutical products and medical devices that benefit patients. I have acquired diverse experience in the health care and life sciences industries spanning discovery, commercialization and regulatory development. My goal is to create and execute business and legal strategies that successfully drive products to market and create overall value for patient care. Capabilities include research design, assay development, clinical trial management, market/financial analysis, data modeling, operational design and management, system dynamics, drafting regulations, stakeholder engagement, intellectual property, licensing and contract drafting/negotiations.

Biosortia Pharmaceuticals United States

Biosortia has opened the door to a new frontier of fascinating compounds that have the potential to materially impact the direction of various chronic diseases.  We are dedicated to discovering new chemical entities for the management of critical chronic disease states such as cancer, neuroscience, infectious disease, and inflammatory disorders to ultimately improve the lives of others.

Value Proposition

Pharma is looking for 3 key things:

1. Novel, never seen before, chemistry from new environments to fight chronic disease

2. Higher levels of potency (nano to Pico molar) to reduce the impact of side-effects

3. New mechanisms of action to fight chronic disease in new and more effective manner

It is well known that micro-organism consortia (not macro) are one of the most biologically active and chemically diverse plant/fungi that are rich in what we call “Defense Mechanism Chemistry”.  Defense Mechanism Chemistry is key in developing drugs for cancer, infectious disease and inflammation.  The problem is no one has been able to get access to this unique chemistry at scale and have the natural products expertise to identify the unique compounds…until now.  

We will provide Pharma with new compounds, rich in “Defense Mechanism Chemistry” on a routine basis that could shorten the discovery cycle by 2-3 years and reduce the overall cost.  

Best Regards,

Kurt Dieck

President and CEO

kdieck@biosortia.com

(614) 296-7076

Year Founded
2008
Biotech Subsector
Biotech Phase of Development
Technology Overview
Mobile, scalable, technology that maintains the integrity of the cell. Biosortia has proprietary methods & technologies that allow us to harvest unique single cellular micro-organism consortia never before studied and in unprecedented quantities targeting 500-1,000kg dry weight solids (DWS). Our technologies and capabilities open up this rich environment of bioactive and chemically diverse compounds for research in the pharmaceutical space for the first time ever. Biosortia’s relationship with NOAA and our Cooperative Research and Development Agreement (CRADA) with them provides Biosortia with identification and access to distinctly qualified harvest locations.
Alliance & Collaborations
(Eli Lilly, AstraZeneca, Eisai and Cubist Pharmaceuticals) with more in the pipeline.
Supporting Metrics or Evidence
Promising Early Results with big pharma (Eli Lilly, AstraZeneca, Eisai and Cubist Pharmaceuticals) with more in the pipeline. • Eli Lilly’s OIDD To date, nearly 100% of Compounds of Interest submitted into Eli Lilly’s Open Innovation Drug Discovery (OIDD) program have been accepted for evaluation…compared to an average 50-60% rejection rate on all submissions. This unprecedented achievement has recently earned Biosortia the inaugural “Collaborator of the Year” award from Lilly. In addition, due to the success in the OIDD Program, Lilly asked to join our Pharma Direct Model and test our fraction library. Initial results across simple 2 assays have produced 10 leads that they desire to follow-up in December 2014. • Big Pharma Interest As of September 30, 2014 we have 4 Big Pharma companies in our Pharma Direct Model (Eli Lilly, AstraZeneca, Cubist and Eisai) with 3 others in the pipeline in various stages of discussions.
Current Financing Needs
Capital- Biosortia has raised 2 rounds of series A Preferred Shares; November 2012 of $1.1M ($29M pre-money valuation) and September 2013 of $3.9M ($35M pre money valuation). In addition, it secured $1 million loan (2% interest) from the State of Ohio, therefore meeting our original desired capital raise of $4-5 million. The current raise is for $3-$6 million dollar to provide the runway to our first licensing agreement in Q4 2015 and drive the scaling of science capability to support the volume from our fraction libraries to be launched in Q1 of 2015.
Current Timeline
Hit rates well in excess of expectations Through our Pharma Direct Partners and 8 academic collaborators, we have over 50% of our fractions active against various therapy areas. This demonstrates both the richness of our compounds and the diversity across multiple therapy areas. With one of our Big Pharma partners alone, we have 48 active fractions/wells, with 20 showing inhibition of cancer growth from 90-99.8%. • Clear pathway to first license event in 2015 We can share with you a clear pathway to a license event in 2015. AZ, Lilly and Eisai are all on schedule to complete their R&D efforts by Q3 of 2015 that will put them in position to determine which compounds of interest they would like to license.
Recent Milestones
To date, nearly 100% of Compounds of Interest submitted into Eli Lilly’s Open Innovation Drug Discovery (OIDD) program have been accepted for evaluation…compared to an average 50-60% rejection rate on all submissions. This unprecedented achievement has recently earned Biosortia the inaugural “Collaborator of the Year” award from Lilly.
Management Team Highlights
Experienced Leadership Team & Advisors Biosortia’s leadership team has over 135 years of healthcare and life science experience with expertise in both pharmaceutical research and the micro-organism aquatic environments with the capability to provide new chemistry in a research ready format and co-develop with Pharma to pre-clinical. -Kurt D. Dieck, President and CEO - Mr. Dieck has spent 30 years in healthcare, including 18 years at Arthur Andersen where he was a global equity partner. In 2002, Kurt joined Cardinal Health, a Fortune 20 public company as a senior executive; where over his tenure he had responsibilities for Strategy, Business Development and ultimately SVP of Business Execution for the $100B pharmaceutical distribution segment. There he worked with a broad spectrum of partners, including brand pharmaceutical manufacturers, throughout the supply chain. Kurt also sits on two other healthcare related boards that are owned by Private Equity firms. -Guy T. Carter, Ph.D., Chief Scientific Officer – Dr. Carter has over 30 years of experience working in Pharmaceutical R&D, primarily in the discovery and development of microbial products. In the course of his career in the pharmaceutical industry he worked as a natural products discovery scientist and advanced through levels of scientific management to the overall leadership of the Natural Products Discovery function at Wyeth Research (later acquired by Pfizer), as well as directing other elements of the Chemical Technologies Department. Guy received a doctorate in Biochemistry from the University of Wisconsin-Madison, and then pursued marine natural products research on an NIH-sponsored post-doctoral fellowship with Kenneth Rinehart at the University of Illinois. -Haiyin He, Ph.D., VP of Research – Dr. He has more than 20 years of experience in pharmaceutical R&D, specializing in discovery of drug leads from natural products and their semi-synthetic analogs in oncology, infectious disease, and other therapeutic areas. Haiyin worked as a principle scientist III and group leader at Wyeth Research and after the merger between Pfizer and Wyeth, he continued on to work at Pfizer World Wide Medicinal Chemistry as an associate research fellow in the area of antibody-drug conjugates for cancer chemotherapy. Haiyin received a doctorate in marine natural products at Scripps Institution of Oceanography with John Faulkner, and then acquired a postdoctoral experience at Chemistry Department, Cornell University with Jon Clardy.
Dr Guy Carter
Dr Guy Carter
LinkedIn logo CSO 
Mr Kurt Dieck
Mr Kurt Dieck
LinkedIn logo President and CEO 

Biotechgate Switzerland

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Year Founded
2003
Alan Jones