MidCap Financial LLC

MidCap Financial is a commercial finance firm that was founded in 28 with offices in Bethesda MD Chicago IL and Los Angeles CA. The firm focuses on providing debt financing solutions to healthcare companies. The firm generally provides loans of around $15 million and is involved in approximately 15 new deals each year. The firm considers companies located around globe.
Josh Groman
Managing Director 
James Taylor
Director 

MP Healthcare Venture Management, Inc. United States

MP Healthcare Ventures is the corporate venture arm of Mitsubishi Tanabe Pharma founded in 2006 and based in Boston Massachusetts. The firm is looking to provide equity capital to seed and venture stage companies in the life science space. The firm is looking to provide companies with $5 million over the lifetime of the investment and plans on making 2-3 investments over the next year. The firm will invest in companies located anywhere around the world.

Tetsuro Iwata
Senior Manager 

MyeloRx United States

MyeloRx is a northern California based biotechnology company. Our lead compound, MRx102, is a small molecule inhibitor of RNA polymerase II. Molecules related to MRx102 have shown clinical efficacy in AML patients in Europe and China.  MRx102 is covered by issued composition of matter patents in the U.S., E.U., China and Japan.  While AML is the initial indication, MRx102 has also been found active in stringent models of pancreatic and lung cancer. Our collaborators include clinical oncologists from MD Anderson Cancer Center, JHU School of Medicine and City of Hope Medical Center. R&D activities have been funded primarily by a $2M NCI SBIR contract. Our strong scientific and management team is lead by Dr. John Musser; it has brought multiple products to market. We are seeking funding to complete an IND which is projected to take less than a year based on the extensive studies completed to date (manufacturing, formulation, toxicology/ PK in rats and dogs etc.)  and a Phase 1 clinical trial in AML patients.

 

Website:
www.myelorx.com
Year Founded
2007
Biotech Subsector
Technology Overview
The lead compound is termed MRx102. It is a prodrug of a purified natural product triptolide that has shown clinical activity in patients with acute myeloid leukemia (AML). Intellectual property MRx102 is covered by issued matter patents in the U.S., E.U., Japan and China. Molecular target The molecular target of the natural product, triptolide, is XPB, a subunit of the transcription factor TFIIH. Binding of XPB by triptolide leads inhibition of transcriptional activation resulting in the blockade of a number of signaling pathways that drive cancer cell proliferation. Safety Triptolide and earlier prodrugs of triptolide have shown toxicity in a variety of clinical studies. We therefore set out to design and develop a safe prodrug, viz. MRx102, using the learning from these earlier studies. In a direct comparative toxicology study performed in rats MRx102 was at least 20 times safer than triptolide. This was due to a favorable pharmacokinetic profile seen both in rats and dogs. Pilot toxicology/PK studies have been completed in rats and dogs; NOAELs have been determined in both species. Thought Leader Studies with MRx102 In collaboration with Dr. Michael Andreeff of the MD Anderson Cancer Center we demonstrated that MRx102 was extremely potent in killing human blast cell and stem cell populations from AML patients. The activity against the stem cell populations may indicate an activity in preventing relapse in these patients. MRx102 was likewise effective in a variety of in vivo xenograft models of AML. Dr. James Eshleman and his colleagues from the JHU School of Medicine have demonstrated the activity of MRx102 in killing pancreatic cancer cells having a variety of genetic abnormalities. Dr. Dan Raz of the City of Hope Medical Center has shown MRx102 effective in models of non-small cell lung cancer and identified a potential biomarker for susceptible cells. Current status MyeloRx has completed a $2M NCI Fast Track SBIR contract that enabled many preclinical activities required for an IND filing. Major remaining activities include the GMP manufacture of drug substance, performance of GLP toxicology in rats and dogs and then completion of the clinical plan for Phase 1 studies in AML and solid tumors. These could be completed to allow IND filing in less than a year.
Alliance & Collaborations
Option agreement for China territories
Current Financing Needs
$5-7M for IND filing/Phase 1 trial
Current Timeline
IND completion in less than one year
IP Status
Issued matter patents worldwide
Recent Milestones
Completion of tox/PK studies in rats/dogs
Neil Ackerman
Vice President Business Development 
John Musser
CEO 

New Leaf Venture Partners

New Leaf Venture Partners is a venture capital company formed in 25 with offices in New York and San Mateo California. The firm currently manages two funds with its most recent fund having closed at $45 million in 27. The firm is looking to make equity investments ranging from $1-$25 million over the lifetime of the investment. The firm looks for companies primarily in the United States and some select opportunities in Europe. The firm plans to make between 1-5 investments over the next year.
Mike Dybbs
Principal 

Novelogics Biotechnology Inc. Canada

Novelogics Biotechnology Inc. has developed unique next generation antibody immunotherapies for treating multiple types of advanced cancers including colon and prostate cancers.  Immunotherapies for cancer are anticipated to be a $35B per year industry in the upcoming years.  

Cancer Drugs with Safety in Mind

From the beginning the novel and specific design of the therapeutic antibody drug minimizes the potential for autoimmune diseases or harming good cells with the bad.  We are dedicated to making cancer treatments that won't make you sick to get you better.

Unecumbered, Founder Owned

Novelogics has developed their assets in an unecumbered envriornment allowing investors to work directly with the team.  At this time the companyis 100% founder owned and undiluted.  Novelogics is anticipating an early exit and has begun discussions with pharmaceutical companies interested in this area.

In addition; a related Medical Device

In addition to the drug, Novelogics has a second PCT Patent pending for a related medical device with a readily available "go to" market in place. 

Year Founded
2013
Biotech Subsector
Medtech Subsector
Biotech Phase of Development
Medtech Phase of Development
Technology Overview
We have developed a panel of patent-protected monoclonal antibodies which bind members of the NKG2D ligand family for use as novel cancer immunotherapies. Studies have shown that cancer cells in part evade the immune system by releasing biologically active molecules, such as NKG2D ligands that interfere with immune cells ability to fight cancer. These ligands are capable of shutting down tumour killing immune effector cells by overwhelming the important activation-type NKG2D receptors, basically putting them to sleep, so tumors can continue to grow undetected. Using our specifically designed antibody drug, we now have the potential to clear out these ligands and restore the immune system in a more balanced way to destroy tumor cells without over-stimulating the immune system or causing adverse side effects.
Alliance & Collaborations
None
Supporting Metrics or Evidence
Proof of concept studies in progress
Current Financing Needs
$2M
Current Timeline
Within 2 years of IND
Current Investors
Founder Funded
IP Status
Two PCT patents pending
Recent Milestones
Have developed a panel of monoclonal antibodies,filed two PCT patents (pending), assembled management and scientific advisory team, completed preliminary invitro and invivo studies and will continue with further characterization before moving on to humanization of the Ab (antibody).
Management Team Highlights
Dr. Cheney, President & CSO has 26 years in R&D (10 years in oncology) including 16 years in drug discovery and has contributed to successful drugs that are either on the market or in late stage clinical trials. Co-Founder, Elaine Allison has 25+ years of corporate management experience.
Ms Elaine Allison
Ms Elaine Allison
LinkedIn logo VP, Business Development 

NuvOx Pharma United States

NuvOx Pharma is developing a series of biologics that increase tissue oxygenation. The company's first market will be in oncology, where increased tumor oxygenation increases the response of tumors to radiation therapy. The company recently started a Phase 1b clinical trial in Glioblastoma Multiforme, and is raising a $2.5 million Series A to complete this trial. Afterwards it will seek partners for a Phase 2b in Glioblastoma, and Phase 1b trials in lung cancer and other oncology indications. After growing to a critical mass in oncology, the company will seek to become standard treatment to increase tissue oxygenation for patients suffering from heart attack, stroke, hemorrhaggic shock, and traumatic brain injury.

Biotech Phase of Development
Current Financing Needs
$2.5 million
Current Investors
Founders, Family, Friends, Desert Angels. $4.2 million Equity, $2.8 million Grants
IP Status
5 patents Issued, 5 pending. FDA grants 12 years regulatory exlusivity for first-in-class biologics.
Recent Milestones
Started Phase 1b Clinical Trial
Dr Evan Unger
Dr Evan Unger
President & CEO 
BIO

A Tucson entrepreneur with 100+ issued patents. Founder of ImaRx Pharmaceutical, which developed 3 FDA approved drugs and was acquired by DuPont.  MD with board certification in Radiology. 

NYU Office of Therapeutics Alliances

The NYU Office of Industrial Liaison (OIL) promotes the commercial development of NYU technologies into products to benefit the public, while providing resources to the University to support its research, education, and patient care missions. NYU OIL also facilitates research collaborations between NYU researchers and industry on projects of mutual interest.

In 2013, NYU launched the Office of Therapeutics Alliances (OTA). OTA is a nimble, "virtual biotech" approach to advance novel therapeutic projects by playing on the strengths of NYU in dissecting disease pathways and those of external, professional capabilities in early stage R&D. OTA identifies NYU projects with potential for addressing unmet needs, delineates the path to therapeutic proof of concept and assembles internal and external resources tailored to each specific project’s needs to maximize the likelihood of successful partnerships with biopharma, new biotech startups or disease foundations. 

Nadim Shohdy
Director, Drug Discovery Partnerships 
Sunil Shah
Partner 
Prashant Shah
Partner 

Orphagen Pharmaceuticals United States

Orphagen’s focus is small molecule discovery at novel drug targets. We create programs leading to first-in-class drugs. Our goal is to partner these with development stage pharmaceutical companies.

We have been first mover in creating three discovery programs for novel targets, including one program that initiated Phase 1 clinical trials with a strategic partner (JT Pharma) in 2013 for autoimmune disease.

We work with novel drug targets from a very productive target class, the nuclear receptors.

Our work has so far been funded by $15 M in federal grants and partnership revenue. Orphagen is in the process of raising equity funding to accelerate current programs.

Orphagen’s lead internal program is for retinitis pigmentosa, the major form of hereditary blindness. Closely following are antagonists to SF-1, a promising target for treatment of Cushing’s syndrome, a life-threatening endocrine disorder, and two cancers with an endocrine connection: prostate cancer and adrenocortical cancer. New target screening may lead to first-in-class programs for glioblastoma, sickle cell anemia, and cancer immunotherapy.

Website:
www.orphagen.com
Year Founded
2000
Biotech Subsector
Biotech Phase of Development
Technology Overview
Orphagen targets unexplored or “orphan” nuclear receptors (NRs), members of a receptor family that includes targets for major breast and prostate cancer drugs and for anti-inflammatory glucocorticoids. Approximately half of the 48 known NRs are targets for drugs on the market or new compounds approaching FDA approval. These marketed drugs generate in excess of $10 billion in annual U.S. sales alone. The remaining nuclear receptors, the orphans, have potential for design of first-in-class drugs. Orphagen has proprietary methodology, experience and knowhow for identifying drug-like small molecules that turn these receptors on and off. Orphagen’s work with these orphans is based on close relationships with academic laboratories.
Alliance & Collaborations
In 2003-6, Orphagen developed a first-in-class drug discovery program for ROR-gamma, a new target for autoimmune diseases such as psoriasis, rheumatoid arthritis and steroid-resistant asthma. Orphagen licensed its discovery-phase ROR-gamma program to JT Pharma in 2008. In 2013, JT Pharma initiated the first Phase 1 clinical trial for this target. BMS, Merck, Pfizer, Janssen, and Amgen also started biotech partnerships for the same target, but not until 2 to 5 years after JT-Pharma and Orphagen. Orphagen has demonstrated ability as a first mover for novel drug targets.
Supporting Metrics or Evidence
Approximately 50% of all industry partnership deals are done early, at a preclinical stage. Upfront payments for first-in-class drugs can reach $10-15 M and have grown substantially in the last 15 years. Combined later milestones are greater: $100 M to $300 M. First-in-class programs, such as Orphagen’s, are likely candidates for accelerated approval by the FDA, which markedly increases their potential for appreciated value. Orphagen plans to partner its discovery and development programs one by one as they mature. Partnership revenue will be used to expand R&D in Orphagen’s discovery pipeline and, when sufficient, to return capital to investors.
Current Financing Needs
$3 M to accelerate the Orphagen program for retinitis pigmentosa and to support a backup program (SF-1). Orphagen continues to receive significant non-dilutive funding from its ongoing partnership, from grants, and from sale of non-proprietary assay services.
Current Timeline
Orphagen expects to have advanced preclinical proof-of-principle data for retinitis pigmentosa and to execute a value-generating partnership for this indication in 2016. This is Orphagen’s most advanced internal program. Additional lead stage partnerships are anticipated in 2017 and beyond. Orphagen is also exploring revenue-generating partnerships in 2015-2016 for new target screening.
Current Investors
Friends and family, only. Orphagen has a single class of stock, Common stock.
IP Status
Orphagen has filed broad use patents for all ligands to two of its major targets where it has been the first to identify small molecule agonists or antagonists. Its screening technology and lead compounds, which are new chemical entities, are maintained as trade secrets.
Recent Milestones
2010-14 Phase 1 SBIRs for: (i) prostate cancer; (ii) endometriosis; (iii) glioblastoma; (iv) retinitis pigmentosa (RP); and (v) Cushing’s syndrome. 2013 File broad use provisional patent application on novel target for RP. 2013 JT Pharma starts Phase 1 clinical trial based on Orphagen strategic partnership. 2014 Structural biology collaboration for SF-1 with pharmaceutical partner. 2014 Initial proof-of-principle for treatment of RP in an animal model of disease. Identification of target co-crystal structure.
Management Team Highlights
Scott Thacher, Ph.D. Founder, CEO and CSO. Investigator for 15 SBIR grants to Orphagen. Concluded Orphagen’s licensing deal with Japan Tobacco. Previous: Investigator at Allergan. Co-founder: Io Therapeutics. Judy Blakemore. Director Business Development. Former interim COO at Onyx. Business development and transactional advisor for small to mid-size biotechnology companies since 1993. Paul Crowe, Ph.D. Director of Biology, Former Senior Director Pharmacology at Neurocrine. Ruo Steensma, Ph.D. Director of Chemistry, Former Director at Structural Genomix.
Dr Scott Thacher
LinkedIn logo CEO 
BIO

Scott Thacher, Ph.D., CEO and Director, founded Orphagen in 2001.  He has 30 years of experience in life sciences research and pharmaceutical R&D and led Orphagen to its first partnership in 2008. Prior to founding Orphagen, Scott directed programs in acne, psoriasis, hyperlipidemia, and diabetes at Allergan. Scott was previously on the biochemistry faculty at the Texas A&M College of Medicine (1986-1993) and was a Staff Fellow at the NIH. He holds a Ph.D. in biophysics from Harvard University and a B.S. in physics (Stanford).

Pappas Ventures

Pappas Ventures is a Venture Capital company based in Durham North Carolina founded in 1994. The firm manages 4 funds for a total of approximately $35 million in assets under management. The firms is currently investing out of its $1 million 4th fund focused exclusively on the life sciences. The firm looks to provide up to $5 million of preferred equity capital in the initial round and up to $1 million over the life of the investment. The firm is very flexible in terms of period to exit but generally looks to exit in around 5 years. The firm plans to make 2-3 investments over the next 6-9 months and will consider companies throughout North America.
Jayson Punwani
Associate