AdeTherapeutics Inc Canada

“AdeTherapeutics’ approach has potential to become standard of care,” says Dr. Greenberg, Vice Chair Obs & Gyn at Brigham and Women’s Hospital and Associate Professor at Harvard Medical School.

Our platform technology which KOL’s have pointed out as a game changer in the area of preventing post operative fibrosis, is poised to create significant value.  The pipeline contains a phase II drug for prevention of post operative fibrosis following pelvic and abdominal surgeries, med devices (collaboration with DSM Biomedical) for spinal surgery and additional opportunities in orthopedics.  

The Company has built a world class team, utilized a capital efficient, highly targeted and focused approach and brought on the necessary strategic partners to bring first-in-class products to the market and establish standard of care for millions of surgeries worldwide.Key value propositions:

•             useful in more procedures than current medical devices

•             significant higher efficacy vs market comparators

•             attractive safety profile & accelerated regulatory pathway

Key Milestones achieved:

  • Phase II trial started
  • Key markets patents issued: USA, EU, Japan
  • Efficacy shown in different tissues areas
  • Two peer reviewed publications in 2014

 

Biotech Subsector
Biotech Phase of Development
Medtech Phase of Development
Technology Overview
. Key publications in 2014 by leading authors in the space supports our novel cellular and molecular approach. Evitar is used at the time of surgery to correct the imbalance in the system brought on by surgical injury which triggers the cascading activation of many pro-inflammatory pathways (including TGF-Beta) that promote adhesion or fibrosis development.
Alliance & Collaborations
DSM Biomedical, Evonik Industries (Mftring) and exploring others
Supporting Metrics or Evidence
publications, preclinical data and POC reading out in early 2015
Current Financing Needs
$5-$6 million
Current Timeline
POC early 2015 for lead indication, moving second indication into the clinic by end of 2015
Current Investors
privately financed by management and board
IP Status
patents issues in major markets
Recent Milestones
phase II trial initated, USA patents issued, two key publications in 2014 in peer reviewed journal
Management Team Highlights
Significant experience in busines devleopment, marketing, clinical, regulatory and buisness development in the hospital space and med devices and therapeutics
Mr Sanj Singh
LinkedIn logo President - CEO 

Aspect Biosystems Canada

Aspect Biosystems uses proprietary bioprinting and cell culture technologies to create high quality living 3D human tissues.  We aim to improve the pre-clinical drug discovery process by providing pharmaceutical companies and researchers with functional living tissues that better predict the human response to drugs.  Our testing platforms will enable pharmaceutical customers to identify failed drugs earlier in the development pipeline, before expensive clinical trials begin.  Aspect Biosystem’s long-term vision is to create human tissues on demand for multiple applications including cosmetics-testing, personalized medicine, diagnostics and regenerative medicine.

Year Founded
2013
Medtech Subsector
Technology Overview
Aspect has proprietary 3D bioprinting and tissue engineering technologies that enable the fabrication of complex, biologically relevant living human tissues.
Alliance & Collaborations
Multiple academic and industry collaborations
Supporting Metrics or Evidence
Multiple functional endpoints confirm biological function of the engineered tissue constructs.
Current Timeline
1st tissue product (airway) is in the process of productisation. Bioprinter development and optimisation of alternative tissue types is underway.
Current Investors
Founders, family and friends, Angels, Seed fund.
IP Status
Bioprinter PCT in place. Full patent application in September 2015
Recent Milestones
2nd place in BC Innovation Council's New Ventures competition (Sept 2014)
Mr Simon Beyer
Co-founder 

HudsonAlpha Institute for Biotechnology United States

The HudsonAlpha Institute for Biotechnology

 

The HudsonAlpha Institute for Biotechnology is a Genomic focused Institute located on a 152-acre bio-medical research campus in Huntsville, Alabama whose mission is to translate scientific breakthroughs in the laboratory into real-world benefits that have a profound impact on people’s lives.

 

HudsonAlpha BioVentures Philanthropic Fund

•       Specific Philanthropic Fund - part of the HudsonAlpha Foundation a tax-exempt, 501(c) 3 non-profit organization.

•       All investments to the Fund are tax-deductible

•       Fund goal is $50 million

•       Targeted toward donors seeking to make a long-term impact in human health and make a difference for thousands, even millions, of people suffering from serious disease.

 

Option 1

HudsonAlpha Foundation invests funds in new or established companies and scientific discoveries. Foundation will have an equity stake and receive a ROI, as companies are successful. The return is reinvested into other companies and HudsonAlpha to further its mission and goals – the multiplier effect.

Option 2

HudsonAlpha Foundation will fund promising intellectual property emanating from HudsonAlpha laboratories.

Option 3

HudsonAlpha Foundation provides grant funding to companies who are relocating to or expanding on the HudsonAlpha campus.

 

All investors/donors will have an opportunity to invest in the future in any and all companies and will be informed regularly on the progress of these companies

Year Founded
2008
Biotech Subsector
Management Team Highlights
Richard M. Meyers Ph.D President and Director of Science •Internationally recognized thought leader in genomics and genetics •Leads scientific collaborations in 18 countries with over 700 researchers and clinicians •Scientific expertise in cancer research including breast, kidney, prostate; neurological disorders including ALS, Parkinson’s disease; psychiatric disorders including schizophrenia, bipolar disorder and major depression. •Former Chair of the Department of Genetics at Stanford University and Director of the Stanford Human Genome Center •Dr. Myers and his lab contributed 11% of the data in the Human Genome Project’s efforts to sequence the first human genome. •Ph.D. in Biochemistry, University of California Berkeley •Performed doctoral work at Harvard University with Dr. Tom Maniatis
John De Michele
Vice President for Advancement 
BIO
JohnDeMicheleJohn De Michele

Vice President for Advancement

John De Michele came to HudsonAlpha in June 2014 from San Diego, bringing with him 30 years of fundraising leadership and nonprofit executive experience. His diverse background ranges from Tufts University to Northwestern University Medical Center Foundation, from the National Jewish Medical and Research Center to the San Diego Symphony, where he mobilized the largest single gift in its history: $125 million. De Michele understands the challenges facing nonprofit leaders today and acts strategically, and tirelessly on behalf of the Institute.

Lipella Pharmaceuticals Inc. United States

Development-stage pharmaceutical company with a platform technology to deliver novel therapeutics to the urinary bladder lumen for the treatment of inflammatory bladder conditions such as overactive bladder and interstitial cystitis. Our portfolio includes prodcuts in pase-I and phase-II clinical trials in the United States and overseas, as well as pre-clinical programs. We also have one program designated as orphan. In addition to therapeutics, Lipella also develops diagnostic agents to be used in connection with medical imaging.

Website:
www.lipella.com
Year Founded
2005
Biotech Subsector
Biotech Phase of Development
Medtech Phase of Development
Technology Overview
Platform technology for the local delivery of novel therapeutics to the urinary bladder
Alliance & Collaborations
Multiple
Current Financing Needs
Can be discussed
Current Investors
Private, non-institutional
IP Status
Multiple US patents, and US and international patent applications
Recent Milestones
LP-09 clinical trial completed 2013, LP-08 IND approved 2014
Management Team Highlights
Small, focused team
Jonathan Kaufman
CEO 

Novelogics Biotechnology Inc. Canada

Novelogics Biotechnology Inc. has developed unique next generation antibody immunotherapies for treating multiple types of advanced cancers including colon and prostate cancers.  Immunotherapies for cancer are anticipated to be a $35B per year industry in the upcoming years.  

Cancer Drugs with Safety in Mind

From the beginning the novel and specific design of the therapeutic antibody drug minimizes the potential for autoimmune diseases or harming good cells with the bad.  We are dedicated to making cancer treatments that won't make you sick to get you better.

Unecumbered, Founder Owned

Novelogics has developed their assets in an unecumbered envriornment allowing investors to work directly with the team.  At this time the companyis 100% founder owned and undiluted.  Novelogics is anticipating an early exit and has begun discussions with pharmaceutical companies interested in this area.

In addition; a related Medical Device

In addition to the drug, Novelogics has a second PCT Patent pending for a related medical device with a readily available "go to" market in place. 

Year Founded
2013
Biotech Subsector
Medtech Subsector
Biotech Phase of Development
Medtech Phase of Development
Technology Overview
We have developed a panel of patent-protected monoclonal antibodies which bind members of the NKG2D ligand family for use as novel cancer immunotherapies. Studies have shown that cancer cells in part evade the immune system by releasing biologically active molecules, such as NKG2D ligands that interfere with immune cells ability to fight cancer. These ligands are capable of shutting down tumour killing immune effector cells by overwhelming the important activation-type NKG2D receptors, basically putting them to sleep, so tumors can continue to grow undetected. Using our specifically designed antibody drug, we now have the potential to clear out these ligands and restore the immune system in a more balanced way to destroy tumor cells without over-stimulating the immune system or causing adverse side effects.
Alliance & Collaborations
None
Supporting Metrics or Evidence
Proof of concept studies in progress
Current Financing Needs
$2M
Current Timeline
Within 2 years of IND
Current Investors
Founder Funded
IP Status
Two PCT patents pending
Recent Milestones
Have developed a panel of monoclonal antibodies,filed two PCT patents (pending), assembled management and scientific advisory team, completed preliminary invitro and invivo studies and will continue with further characterization before moving on to humanization of the Ab (antibody).
Management Team Highlights
Dr. Cheney, President & CSO has 26 years in R&D (10 years in oncology) including 16 years in drug discovery and has contributed to successful drugs that are either on the market or in late stage clinical trials. Co-Founder, Elaine Allison has 25+ years of corporate management experience.
Ms Elaine Allison
Ms Elaine Allison
LinkedIn logo VP, Business Development 

ORIG3N United States

ORIG3N is a biotech company based in Boston, MA. The scientific mission is to deliver a disease-modeling platform targeting rare genetically inherited diseases. By advancing screening projects using iPSC-derived differentiated cells and rapidly delivering the resulting data to inform therapeutic decisions, ORIG3N will replace trial & error guess work of treating disease and enable longer, healthier lives. 

Website:
www.orig3n.com
Biotech Subsector
Medtech Subsector
Technology Overview
ORIG3N specializes in the generation of patient specific iPSC-derived cardiomyocytes, neurons, and hepatocytes. We have also built a unique iPSCs bank, called Life Capsule, with fully consented samples from patients with various neurodegenerative and cardiac diseases. Utilizing the diverse patient population from Life Capsule, we are able to provide patient and disease specific cell models.
Management Team Highlights
Successful repeat entrepreneurs, the founding team has 60+ years of experience in life science. Robin Smith, the CEO has 3 prior successful exits - the most recent two were VC backed and both sold to publicly traded companies; provided 24:1 return and 74%IRR to prior investors.
James Lovgren
James Lovgren
LinkedIn logo CBO 
Robin Smith
CEO 

Precision NanoSystems Canada

Precision NanoSystems Inc. (“PNI”) has developed proprietary technology (NanoAssemblr) and companion Reagent Kits (SUB9KITS) that enable the simple manufacture of novel nanoparticles that are used to delivery genetic and small molecule medicines (nanomedicines). Nanomedicines are the "FedEx" of the health-care industry and are used for cell-specific delivery of research tools, diagnostic imaging agents and drugs to study, diagnose and treat disease. PNI's products are commercialized and in high demand from many of leading RNA and small molecule therapeutic biotechnology and pharmaceutical companies.  http://www.precisionnanosystems.com/products/

Year Founded
2010
Biotech Phase of Development
Current Financing Needs
PNI is currently raising Series A financing.
Recent Milestones
PNI launched its flagship NanoAssemblr Benchtop and SUB9KIT products in H2 2013. Since that time, PNI has seen significant latent demand for its products and is rapid expanding product manufacturing to satisfy market need. Additionally, PNI has achieved important technical milestones in it's large-scale nanomedicine platform and SUB9KIT products.
Management Team Highlights
PNI’s management, directors & advisors have collectively contributed to over 100 patents and 500 papers, started over 20 biotech companies, raised over $1B in financing/deals and have brought 4 drugs to market. PNI’s CEO, Dr. James Taylor has over 10 years of experience in commercializing biotech and has lead PNI since invention. PNI’s COO, Dr. Euan Ramsay, has 13 years commercializing biotech, has secured over $40M in leveraged financing, and has developed nanomedicines to clinical trials.
James Taylor
CEO 
Euan Ramsay
COO 

Promosome LLC United States

Promosome is a synthetic biology company founded to commercialize the discoveries of the late Nobel Laureate, Dr. Gerald M. Edelman, and colleague Dr. Vincent P. Mauro of The Scripps Research Institute (TSRI) in La Jolla, CA. Leveraging Dr. Edelman’s and Mauro's unparalleled expertise in the area of mRNA translation and the resulting technologies they pioneered, Promosome offers technology licensing opportunities to biotherapeutic and bioindustrial companies seeking to dramatically improve efficiencies in expression, secretion, and potentially biotherapeutic safety and dose tolerance.

In March 2014, GEHC and Promosome executed an agreement to license a subset of Promosome’s initial technology suite in support of their mammalian cell line development ambitions.

Promosome operates a developmental center in the Torrey Pines section of San Diego which focuses on expanding its mRNA translation-based toolset as well as identifying and developing a pipeline of proprietary proteins which can be differentiated by their unique manufacturing attributes (higher yields, greater homogeneity, etc.) and quite possibly by their safety profile in clinical use.

Year Founded
2004
Biotech Phase of Development
Technology Overview
Ribosomal Engagement mRNA Translation
Alliance & Collaborations
GE Healthcare Life Sciences
Current Financing Needs
5-10M USD
Current Investors
HWI
IP Status
Varying from Provisional to Granted
Recent Milestones
Exclusive Mammalian to GEHC
Management Team Highlights
Proven & Expanding
John Manzello
President & CEO 

Tangen Biosciences United States

Tangen Biosciences is an early stage diagnostic instrument company that has developed a group of novel technologies that together enable rapid, portable, lab-free, and very low cost molecular diagnostics at the point of care.   

The Tangen platform will amplify and detect specific nucleic acid sequences obtained from a variety of source samples, including clinical specimens such as blood, tissue and sputum, as well as environmental samples obtained from water, soil or food, for example.  The first application of the Tangen platform is the detection and diagnosis of Tuberculosis using DNA extracted from sputum samples, using the Tangen Sputum Processing assay kit

Year Founded
2012
Biotech Subsector
Indication
Biotech Phase of Development
Current Financing Needs

Additional $0.5-1M to close seed round

John Nobile
President and CEO 
John Davidson
CSO