AbCellera Canada

AbCellera has developed a next generation technology for the analysis and screening of naturally derived immune repertoires. This platform uses high-throughput single cell analysis to enable the discovery of naturally derived monoclonal antibodies with unmatched speed, efficiency, and assay flexibility. By eliminating the need to culture cells this approach may be applied to antibody discovery from non-traditional host species, including rabbits and llamas, and achieves industry-leading capabilities in isolating antibodies from patient samples, with applications in infectious disease and autoimmunity.

AbCellera is engaged in antibody discovery projects with early partners, including biotech and pharma companies, and is also initiating internal programs aimed at using immune profiling for target identification and lead molecule discovery.

We are looking for Series A financing from strategic investors, as well as new partnerships with antibody drug development companies.

 

Dr Carl Hansen
Dr Carl Hansen
CEO & President 

apceth GmbH & Ko. KG Germany

apceth is a privately held German Biotech company focused on the development and clinical implementation of innovative biopharmaceuticals based on cell and gene therapy in the field of oncology.

Enabling platform technology for genetic modification of mesenchymal stem cells (MSC) to be used as drug shuttle to target tumors or other areas of interest.

Clinical development:

phase I with modified MSC in gastro-intestinal tumors completed (12/2014)

phase I/II with MSC for vascular disease completed

strong clinical pipeline based on genetic modification of MSC

Implementation of allogeneic cell bank system to accomodate off-the-shelf production of cell-based pharmaceuticals.

Strong network and IP,

interesting preclinical pipeline addressing oncology, lung disease, inflammation.

Secure financing by German Family Offic. Looking for partner/ cofinancing for ongoing clinical development (phase II/III)

Website:
www.apceth.com
Year Founded
2007
Biotech Phase of Development
Medtech Phase of Development
Technology Overview
platform technology for genetic modification of mesenchymal cells
Alliance & Collaborations
strong network with industry and academic partners , national and international
Current Financing Needs
financing planned for 2016 for clinical development phase II
Current Timeline
phase II results oncology in 2016
Current Investors
family offices: Santo-holding and FCP, Munich, Germany
IP Status
more than 30 patents granted for cell and gene therapy/ gene delivery
Recent Milestones
phase I with genetically modified MSC in Oncology completed, First in man
Christine Günther
CEO 
Mr Helmut Jeggle
CFO 

Fusion Genomics Corporation Canada

Fusion Genomics Corp (FG) is a molecular diagnostic test  development company that is introducing diagnostic kits with companion analysis software that offer superior clinical information, faster turn-around-times and ease of use for hospitals and clinical laboratories. Fusion is the first of two companies in the world to bring a validated Next Generation Sequencing (NGS) diagnostic test complete with highly secure cloud based analytical service for childhood cancers (ChildSeq-RNA SRCT) into the clinic. This test was validated in the renowned medical testing facility at the Texas Children Hospital, Baylor College of Medicine.

FG is completing development of kits for facilitating absolute diagnosis of pediatric and adult blood cancers. In addition, FG has partnered with the Royal Tropical Institute (Dutch: Koninklijk Instituut voor de Tropen; KIT) a World Health Organization reference diagnostic laboratory for infectious diseases to design the next generation of assays for the detection of infectious diseases including drug-resistant forms of tuberculosis, influenza, hepatitis and hemorrhagic fevers including Ebola.

Year Founded
2013
Biotech Subsector
Medtech Subsector
Biotech Phase of Development
Medtech Phase of Development
Technology Overview

Fusion Genomics Corporation (FG) develops molecular diagnostic tests that utilize next-generation sequencing (NGS) technologies. All of FG’s tests can be used with any of the widely adopted NGS instruments on the market. Data is analyzed using FGF’s secure FusionCloud, providing diagnosis –enabling DNA sequence information to the clinician.

Most NGS based diagnostic efforts can be divided into two categories: 1) whole genome sequencing (WGS), where the entire DNA of an individual (or a pathogen) is sequenced, and 2) target-capture sequencing (TCS), where only diseased portions of DNA are sequenced. TCS produces 1000 times less data than WGS. The expensive computational resources required for analysis of WGS data prevents it from being adopted for routine clinical use. Therefore, TCS is more suitable and appealing in frontline diagnostic environments.

TCS uses either PCR or “DNA baits” as the underlying technology to “capture” disease-specific regions of the genome. PCR-based methods suffer from limitations described earlier. FG uses proprietary Quantum ProbesTM, an enhanced form of DNA baits, in all its tests. Quantum ProbesTM allow for nearly limitless expansion of genetic targets and rapid development of new tests as well as patentable techniques that are beyond the capacity of PCR. The superior advantage of Quantum ProbeTM, coupled with FusionCloud analysis and reporting, will drive the successful adoption of the tests. 

Alliance & Collaborations
Texas Children Hospital, Baylor College of Medicine (Houston, USA), British Columbia Centre for Disease Control (Vancouver, Canada), Royal Tropical Institute / Koninklijk Instituut voor de Tropen (Amsterdam, Netherlands)
Supporting Metrics or Evidence

The Fusion Genomics team published a very well received peer-reviewed publication which demonstrated that their technology was more sensitive, accurate, rapid and comprehensive than current industry standards such as PCR and FISH.  This study can be found at here.

Current Financing Needs

 $0.5-1M to complete seed round

Current Investors

Founders, board members, family and friends.

IP Status

Patent applications are pending.

Management Team Highlights

Fusion Genomics Corporation’s team has established expertise in next-generation sequencing, diagnostic test and software development, and information technology.

Mohammed Qadir, PhD., Chief Executive Officer and Chief Scientific Officer has over 17 years of research experience; the last 10 were at the British Columbia Cancer Agency. As part of his early training, he worked with world-renowned experts in genomics and drug development and is the co-inventor of the ChildSeq assay and ChildDecode.

Greg Stazyk, Chief Technical Officer has over 20 years of experience in senior positions in the IT industry. Mr. Stazyk was the IT lead for one of Canada’s largest bioinformatics computing platform at the BC Cancer Agency’s Genome Sciences Centre (GSC). Mr. Stazyk was the senior manager at PMC-Sierra Inc. responsible for its global computer systems operation.

Brian Kwok, VP of Product Development has close to 10 years of experience in molecular biology and genomic technologies including leading edge next-generation sequencing. Mr. Kwok has worked in combinatorial drug screening and led the development of the ChildSeq assay.

Dr. Poul Sorensen MD, PhD: Board member and clinical expert. Dr. Sorensen is a world-renowned pediatric pathologist and is the Johal Chair in Childhood Cancer Research at the University of British Columbia, as well as a professor in the Department of Pathology and a Senior Scientist at the BC Cancer Research Agency (Vancouver, Canada). Dr. Sorensen is also the Chair of the Translational Research committee of the Children’s Oncology Group.

Mohammed Qadir
Chief Scientific Officer 

HudsonAlpha Institute for Biotechnology United States

The HudsonAlpha Institute for Biotechnology

 

The HudsonAlpha Institute for Biotechnology is a Genomic focused Institute located on a 152-acre bio-medical research campus in Huntsville, Alabama whose mission is to translate scientific breakthroughs in the laboratory into real-world benefits that have a profound impact on people’s lives.

 

HudsonAlpha BioVentures Philanthropic Fund

•       Specific Philanthropic Fund - part of the HudsonAlpha Foundation a tax-exempt, 501(c) 3 non-profit organization.

•       All investments to the Fund are tax-deductible

•       Fund goal is $50 million

•       Targeted toward donors seeking to make a long-term impact in human health and make a difference for thousands, even millions, of people suffering from serious disease.

 

Option 1

HudsonAlpha Foundation invests funds in new or established companies and scientific discoveries. Foundation will have an equity stake and receive a ROI, as companies are successful. The return is reinvested into other companies and HudsonAlpha to further its mission and goals – the multiplier effect.

Option 2

HudsonAlpha Foundation will fund promising intellectual property emanating from HudsonAlpha laboratories.

Option 3

HudsonAlpha Foundation provides grant funding to companies who are relocating to or expanding on the HudsonAlpha campus.

 

All investors/donors will have an opportunity to invest in the future in any and all companies and will be informed regularly on the progress of these companies

Year Founded
2008
Biotech Subsector
Management Team Highlights
Richard M. Meyers Ph.D President and Director of Science •Internationally recognized thought leader in genomics and genetics •Leads scientific collaborations in 18 countries with over 700 researchers and clinicians •Scientific expertise in cancer research including breast, kidney, prostate; neurological disorders including ALS, Parkinson’s disease; psychiatric disorders including schizophrenia, bipolar disorder and major depression. •Former Chair of the Department of Genetics at Stanford University and Director of the Stanford Human Genome Center •Dr. Myers and his lab contributed 11% of the data in the Human Genome Project’s efforts to sequence the first human genome. •Ph.D. in Biochemistry, University of California Berkeley •Performed doctoral work at Harvard University with Dr. Tom Maniatis
John De Michele
Vice President for Advancement 
BIO
JohnDeMicheleJohn De Michele

Vice President for Advancement

John De Michele came to HudsonAlpha in June 2014 from San Diego, bringing with him 30 years of fundraising leadership and nonprofit executive experience. His diverse background ranges from Tufts University to Northwestern University Medical Center Foundation, from the National Jewish Medical and Research Center to the San Diego Symphony, where he mobilized the largest single gift in its history: $125 million. De Michele understands the challenges facing nonprofit leaders today and acts strategically, and tirelessly on behalf of the Institute.

Norfolk Medical Products Inc.

Norfolk Medical pioneered the oncology market in 1981 by developing one of the first vascular access ports for long-term access.  Since then, we have continued to develop innovative cutting-edge medical devices.  Our latest development is a device for diabetes that allows the body to be insulin independent.  Our device is the world's first active immunoisolation device that facilitates the exchange of oxygen, nutrients, and waste products while protecting against the bodies immune response without the use of additional drugs or immunosuppressant’s.  We are confident that the basic principles of the device can be applied to other applications from anemia and liver failure (NASH) to ALS.  We are currently in the pre-clinical stage of research and are actively looking for a strategic partner to develop this product. 


Biotech Subsector
Biotech Phase of Development
Medtech Phase of Development
Jordan Dalton
COO 

Precision NanoSystems Canada

Precision NanoSystems Inc. (“PNI”) has developed proprietary technology (NanoAssemblr) and companion Reagent Kits (SUB9KITS) that enable the simple manufacture of novel nanoparticles that are used to delivery genetic and small molecule medicines (nanomedicines). Nanomedicines are the "FedEx" of the health-care industry and are used for cell-specific delivery of research tools, diagnostic imaging agents and drugs to study, diagnose and treat disease. PNI's products are commercialized and in high demand from many of leading RNA and small molecule therapeutic biotechnology and pharmaceutical companies.  http://www.precisionnanosystems.com/products/

Year Founded
2010
Biotech Phase of Development
Current Financing Needs
PNI is currently raising Series A financing.
Recent Milestones
PNI launched its flagship NanoAssemblr Benchtop and SUB9KIT products in H2 2013. Since that time, PNI has seen significant latent demand for its products and is rapid expanding product manufacturing to satisfy market need. Additionally, PNI has achieved important technical milestones in it's large-scale nanomedicine platform and SUB9KIT products.
Management Team Highlights
PNI’s management, directors & advisors have collectively contributed to over 100 patents and 500 papers, started over 20 biotech companies, raised over $1B in financing/deals and have brought 4 drugs to market. PNI’s CEO, Dr. James Taylor has over 10 years of experience in commercializing biotech and has lead PNI since invention. PNI’s COO, Dr. Euan Ramsay, has 13 years commercializing biotech, has secured over $40M in leveraged financing, and has developed nanomedicines to clinical trials.
James Taylor
CEO 
Euan Ramsay
COO