Sam Murphy United States

IMS Health Capital (IMSHC) is a niche life-science focused investment bank which manages financing transactions, and advises on M&A and licensing/partnering transactions.

IMS Health Capital (IMSHC) is a fully owned subsidiary of IMS Health, Inc. (www.imshealth.com) and affiliated with IMS Consulting Group (www.imscg.com).

IMSHC has privileged access to a vast array of IMS Health’s resources and connections and can help prepare a compelling value proposition and put you in touch with the right interested parties.  Our team has extensive life-science industry experience and can provide support at any and all stages of the transaction process.  Unlike most investment banks or business development consultants, IMSHC has immense strategic partnering capabilities and can work with companies on both partnering and financing efforts.  Given our unique positioning and access to a vast array of information and relationships, we see a high volume of opportunities.

IMSHC is a SEC/FINRA licensed broker dealer and a wholly owned subsidiary of IMS Health, Inc.  IMS Health Inc. is publicly traded on the NYSE under the ticker “IMS”, and is the world’s leading information, services and technology company in the Life Sciences sector.  Customers of IMS Health’s data and consulting services include most of the top names in pharmaceutical, medical device and consumer health manufacturers and distributors, providers, payers, government agencies, policymakers, researchers and the financial community (www.imshealth.com).

Website:
www.imscg.com
Service Provider Type
Unique Capabilities
Life-Science focused and IMS Health resources
IMS Health Capital, Inc.
Vice President 

John Musser United States

MyeloRx is a northern California based biotechnology company. Our lead compound, MRx102, is a small molecule inhibitor of RNA polymerase II. Molecules related to MRx102 have shown clinical efficacy in AML patients in Europe and China.  MRx102 is covered by issued composition of matter patents in the U.S., E.U., China and Japan.  While AML is the initial indication, MRx102 has also been found active in stringent models of pancreatic and lung cancer. Our collaborators include clinical oncologists from MD Anderson Cancer Center, JHU School of Medicine and City of Hope Medical Center. R&D activities have been funded primarily by a $2M NCI SBIR contract. Our strong scientific and management team is lead by Dr. John Musser; it has brought multiple products to market. We are seeking funding to complete an IND which is projected to take less than a year based on the extensive studies completed to date (manufacturing, formulation, toxicology/ PK in rats and dogs etc.)  and a Phase 1 clinical trial in AML patients.

 

Website:
www.myelorx.com
Year Founded
2007
Biotech Subsector
Technology Overview
The lead compound is termed MRx102. It is a prodrug of a purified natural product triptolide that has shown clinical activity in patients with acute myeloid leukemia (AML). Intellectual property MRx102 is covered by issued matter patents in the U.S., E.U., Japan and China. Molecular target The molecular target of the natural product, triptolide, is XPB, a subunit of the transcription factor TFIIH. Binding of XPB by triptolide leads inhibition of transcriptional activation resulting in the blockade of a number of signaling pathways that drive cancer cell proliferation. Safety Triptolide and earlier prodrugs of triptolide have shown toxicity in a variety of clinical studies. We therefore set out to design and develop a safe prodrug, viz. MRx102, using the learning from these earlier studies. In a direct comparative toxicology study performed in rats MRx102 was at least 20 times safer than triptolide. This was due to a favorable pharmacokinetic profile seen both in rats and dogs. Pilot toxicology/PK studies have been completed in rats and dogs; NOAELs have been determined in both species. Thought Leader Studies with MRx102 In collaboration with Dr. Michael Andreeff of the MD Anderson Cancer Center we demonstrated that MRx102 was extremely potent in killing human blast cell and stem cell populations from AML patients. The activity against the stem cell populations may indicate an activity in preventing relapse in these patients. MRx102 was likewise effective in a variety of in vivo xenograft models of AML. Dr. James Eshleman and his colleagues from the JHU School of Medicine have demonstrated the activity of MRx102 in killing pancreatic cancer cells having a variety of genetic abnormalities. Dr. Dan Raz of the City of Hope Medical Center has shown MRx102 effective in models of non-small cell lung cancer and identified a potential biomarker for susceptible cells. Current status MyeloRx has completed a $2M NCI Fast Track SBIR contract that enabled many preclinical activities required for an IND filing. Major remaining activities include the GMP manufacture of drug substance, performance of GLP toxicology in rats and dogs and then completion of the clinical plan for Phase 1 studies in AML and solid tumors. These could be completed to allow IND filing in less than a year.
Alliance & Collaborations
Option agreement for China territories
Current Financing Needs
$5-7M for IND filing/Phase 1 trial
Current Timeline
IND completion in less than one year
IP Status
Issued matter patents worldwide
Recent Milestones
Completion of tox/PK studies in rats/dogs
MyeloRx
CEO 

Stephen Nagler

MedPro Investors is a group of accredited investors based in New York USA. The group is made up of over 1 healthcare professionals seeking to invest in technologies that significantly advance the standard of care. The group considers companies at a range of stages and is geographically agnostic. Since the members are investing their own capital the investment size and capital structure are highly flexible. The group is actively seeking new investment opportunities and is open to leading financing rounds.
MedPro Investors
Executive Director 
OMRF Technology Ventures
Vice President 

Imran Nasrullah

Boehringer Ingelheim was founded in 1885 and is based in Ingelheim am Rhein Germany. The firm invests by means of in-licensing and acquisitions and is primarily focused on respiratory diseases cardiovascular diseases metabolic diseases oncology diseases of the central nervous system and immunology. Boehringer Ingelheim also invests in veterinary medicine.

Boehringer Ingelheim
Director Innovation Sourcing 

Jeff Nedved

TriNet
Regional Sales Consultant, Life Sciences and Biotech 

Barbara Nelsen United States

Sofia Angel Group is a group of angel investors based in Minneapolis, Minnesota. The group solely focuses on investing in women-led businesses where women are the founders, or women are on the senior management team. Sofia Angel Group does not have a specific timeframe to make an investment, however would make an allocation by the end of 2013 if a compelling opportunity is identified. The group typically invests around $100,000 per company, however has the ability to invest up to $3 million through co-investments from the group’s members.

Sofia Angel Fund

John Nelson

Genrich is a Multi-Family office founded and based in Long Beach California with additional offices in New York Toronto and London. The firm is looking to make equity and venture debt investments into companies in the life science space ranging from $2-$2 million over the lifetime of the investment often set up in tranches. Ideal candidates will be located 2 hours driving distance from one of the firm?s offices Boston and Chicago will also be considered. The firm is actively seeking new investment opportunities.
Genrich
Managing Director 

Carey Ng United States

Mesa Verde Venture Partners is a Venture Capital company founded in 2006. The firm is currently making investments out of its 2nd fund that had its first close in 2013. The firm makes primarily equity investment into seed and early stage rounds ranging from $500,000 to $1 million initially and up to $1.5 million over the lifetime of the investment. The firm is focused on companies located in the Southwestern United States although they are open to review companies from throughout the US. The firm could make as many as 3 new investments over the next 6-9 months.

Year Founded
2006
Investor Type
Biotech Phase of Development
Medtech Phase of Development
Capital Structure Preference
Investment Stage Preference
Mesa Verde Venture Partners
Managing Director