Ron Demuth

Torrey Pines Investment (TPI) was founded in 22 and is based in San Diego CA. The firm has raised two funds and also invests in drug development via a partnership with BioMotiv. TPI makes venture-stage minority equity investments and prefers act as a co-investor but also leads rounds on occasion. The firm invests internationally.

Torrey Pines Investment
President 

Steve DeNelsky United States

Life Sciences Alternative Funding (LSAF) founded in 213 is a direct investment firm based in White Plains New York. The firm focuses exclusively on providing debt capital for commercial-stage medical technology companies. The firm can allocate between USD 1M-5M per investment. The firm looks to provide flexible ?tailor-made? financing solution to companies. The firm can invest globally and is currently seeking new investment opportunities.

Life Sciences Alternative Funding
President 

Eric Desai United States

Greenhouse Capital Partner is a venture capital firm that was founded in 2006 and is based in Sausalito, California. The firm selectively makes equity investments into life science companies in seed stage and series A financing round, but it also provides growth equity to highly capital efficient companies that can achieve cash flow break-even within two years. The typical investment size ranges from $0.25 million to $2 million.The firm focuses on investments in US based companies.

Greenhouse Capital Partners
Principal 

Cornelius Diamond United States

Website:
www.predict.net
Year Founded
2010
Biotech Subsector
Biotech Phase of Development
Technology Overview
Assay to predict bleeding; paired with various cardiovascular drugs, also developed by the company, to displace existing therapeutics from a safety perspective
Alliance & Collaborations
Glycotope GmbH, Cellonic SA, Qualigen Inc.
Supporting Metrics or Evidence
7 published papers on c-Fn predicting bleeding in various neurological indications
Current Financing Needs
$1.5M
Current Timeline
on-market 2018
Current Investors
NACP, Private Offices
IP Status
3 granted patents on main technology; several more in various WW phases
Recent Milestones
Private investment of more than $1Mio to progress first therapeutic/companion Dx assay to market
Management Team Highlights
Divestment of oncology Dx business
Prediction BioSciences
Founder & CEO 

Mr Kurt Dieck United States

Biosortia has opened the door to a new frontier of fascinating compounds that have the potential to materially impact the direction of various chronic diseases.  We are dedicated to discovering new chemical entities for the management of critical chronic disease states such as cancer, neuroscience, infectious disease, and inflammatory disorders to ultimately improve the lives of others.

Value Proposition

Pharma is looking for 3 key things:

1. Novel, never seen before, chemistry from new environments to fight chronic disease

2. Higher levels of potency (nano to Pico molar) to reduce the impact of side-effects

3. New mechanisms of action to fight chronic disease in new and more effective manner

It is well known that micro-organism consortia (not macro) are one of the most biologically active and chemically diverse plant/fungi that are rich in what we call “Defense Mechanism Chemistry”.  Defense Mechanism Chemistry is key in developing drugs for cancer, infectious disease and inflammation.  The problem is no one has been able to get access to this unique chemistry at scale and have the natural products expertise to identify the unique compounds…until now.  

We will provide Pharma with new compounds, rich in “Defense Mechanism Chemistry” on a routine basis that could shorten the discovery cycle by 2-3 years and reduce the overall cost.  

Best Regards,

Kurt Dieck

President and CEO

kdieck@biosortia.com

(614) 296-7076

Year Founded
2008
Biotech Subsector
Biotech Phase of Development
Technology Overview
Mobile, scalable, technology that maintains the integrity of the cell. Biosortia has proprietary methods & technologies that allow us to harvest unique single cellular micro-organism consortia never before studied and in unprecedented quantities targeting 500-1,000kg dry weight solids (DWS). Our technologies and capabilities open up this rich environment of bioactive and chemically diverse compounds for research in the pharmaceutical space for the first time ever. Biosortia’s relationship with NOAA and our Cooperative Research and Development Agreement (CRADA) with them provides Biosortia with identification and access to distinctly qualified harvest locations.
Alliance & Collaborations
(Eli Lilly, AstraZeneca, Eisai and Cubist Pharmaceuticals) with more in the pipeline.
Supporting Metrics or Evidence
Promising Early Results with big pharma (Eli Lilly, AstraZeneca, Eisai and Cubist Pharmaceuticals) with more in the pipeline. • Eli Lilly’s OIDD To date, nearly 100% of Compounds of Interest submitted into Eli Lilly’s Open Innovation Drug Discovery (OIDD) program have been accepted for evaluation…compared to an average 50-60% rejection rate on all submissions. This unprecedented achievement has recently earned Biosortia the inaugural “Collaborator of the Year” award from Lilly. In addition, due to the success in the OIDD Program, Lilly asked to join our Pharma Direct Model and test our fraction library. Initial results across simple 2 assays have produced 10 leads that they desire to follow-up in December 2014. • Big Pharma Interest As of September 30, 2014 we have 4 Big Pharma companies in our Pharma Direct Model (Eli Lilly, AstraZeneca, Cubist and Eisai) with 3 others in the pipeline in various stages of discussions.
Current Financing Needs
Capital- Biosortia has raised 2 rounds of series A Preferred Shares; November 2012 of $1.1M ($29M pre-money valuation) and September 2013 of $3.9M ($35M pre money valuation). In addition, it secured $1 million loan (2% interest) from the State of Ohio, therefore meeting our original desired capital raise of $4-5 million. The current raise is for $3-$6 million dollar to provide the runway to our first licensing agreement in Q4 2015 and drive the scaling of science capability to support the volume from our fraction libraries to be launched in Q1 of 2015.
Current Timeline
Hit rates well in excess of expectations Through our Pharma Direct Partners and 8 academic collaborators, we have over 50% of our fractions active against various therapy areas. This demonstrates both the richness of our compounds and the diversity across multiple therapy areas. With one of our Big Pharma partners alone, we have 48 active fractions/wells, with 20 showing inhibition of cancer growth from 90-99.8%. • Clear pathway to first license event in 2015 We can share with you a clear pathway to a license event in 2015. AZ, Lilly and Eisai are all on schedule to complete their R&D efforts by Q3 of 2015 that will put them in position to determine which compounds of interest they would like to license.
Recent Milestones
To date, nearly 100% of Compounds of Interest submitted into Eli Lilly’s Open Innovation Drug Discovery (OIDD) program have been accepted for evaluation…compared to an average 50-60% rejection rate on all submissions. This unprecedented achievement has recently earned Biosortia the inaugural “Collaborator of the Year” award from Lilly.
Management Team Highlights
Experienced Leadership Team & Advisors Biosortia’s leadership team has over 135 years of healthcare and life science experience with expertise in both pharmaceutical research and the micro-organism aquatic environments with the capability to provide new chemistry in a research ready format and co-develop with Pharma to pre-clinical. -Kurt D. Dieck, President and CEO - Mr. Dieck has spent 30 years in healthcare, including 18 years at Arthur Andersen where he was a global equity partner. In 2002, Kurt joined Cardinal Health, a Fortune 20 public company as a senior executive; where over his tenure he had responsibilities for Strategy, Business Development and ultimately SVP of Business Execution for the $100B pharmaceutical distribution segment. There he worked with a broad spectrum of partners, including brand pharmaceutical manufacturers, throughout the supply chain. Kurt also sits on two other healthcare related boards that are owned by Private Equity firms. -Guy T. Carter, Ph.D., Chief Scientific Officer – Dr. Carter has over 30 years of experience working in Pharmaceutical R&D, primarily in the discovery and development of microbial products. In the course of his career in the pharmaceutical industry he worked as a natural products discovery scientist and advanced through levels of scientific management to the overall leadership of the Natural Products Discovery function at Wyeth Research (later acquired by Pfizer), as well as directing other elements of the Chemical Technologies Department. Guy received a doctorate in Biochemistry from the University of Wisconsin-Madison, and then pursued marine natural products research on an NIH-sponsored post-doctoral fellowship with Kenneth Rinehart at the University of Illinois. -Haiyin He, Ph.D., VP of Research – Dr. He has more than 20 years of experience in pharmaceutical R&D, specializing in discovery of drug leads from natural products and their semi-synthetic analogs in oncology, infectious disease, and other therapeutic areas. Haiyin worked as a principle scientist III and group leader at Wyeth Research and after the merger between Pfizer and Wyeth, he continued on to work at Pfizer World Wide Medicinal Chemistry as an associate research fellow in the area of antibody-drug conjugates for cancer chemotherapy. Haiyin received a doctorate in marine natural products at Scripps Institution of Oceanography with John Faulkner, and then acquired a postdoctoral experience at Chemistry Department, Cornell University with Jon Clardy.
Mr Kurt Dieck
Biosortia Pharmaceuticals
LinkedIn logo President and CEO 

Kevin Dillon United States

We have developed the CloSys Hemostatic Device (HD)  - a highly differentiated technology for vascular closure after an interventional cardiology or peripheral procedure.  CloSys HD is unique in that it facilitates rapid closure but leaves NO foreign material behind in the patient.  It does this using a patented technology that eliminates heparin (anti-coagulant) from a small amount of the patient's blood and re-infuses this back to the puncture site and around the entire artery.  The de-heparinized blood rapidly and safely forms a clot to seal the artery naturally.  There are several other unique attributes of this product.  First  - it is the only product that will also seal "backsticks" or inadvertant punctures that go through the other side of the artery.  Backsticks are a leading cause of retroperitoneal hemorrhage.  Second - it preserves immediate re-access at the same site in the advent of an emergency.  

There is also an important economic value proposition offered by CloSys HD.  It will have a very low cost of goods so it could be sold for a price that will allow high margins to the manufacturer and cost savings to the hospital.  

We are approximately 25% of the way through a US pivotal trial and to date all performance and safety endpoints have been met.  There is a highly experienced management team and exceptional Board of Directors now associated with the company.    

Year Founded
2005
Main Sector
Medtech Subsector
Indication
Medtech Phase of Development
Technology Overview
CloSys HD consists a simple to use two component system. One component is a "wall locater" that is deployed inside the artery to achieve temporary hemostasis. The other component is a syringe with a special "reactor" in the tip that contains glass beads coated with a proprietary polymer. Blood withdrawn through the sheath passes through the reactor in the syringe which instantaneously removes heparin from the blood. The de-heparinzed blood is re-infused and forms a clot at the puncture site and around the artery.
Alliance & Collaborations
Rex Healthcare (part of UNC) in Raleigh, NC. Cardiovascular Institute of the South in Lafayette, LA, Deborah Heart and Lung in Brown Mills, NJ, and Mt. Sinai Medical Center in Miami, FL
Supporting Metrics or Evidence
Early results from an IDE trial. In this key performance endpoints of time to hemostasis and time to ambulation are being met. Safety endpoint of no unanticipated adverse events being met too. Results from two earlier studies performed in Europe as well numerous GLP and bench test reports have demonstrated effectiveness and safety.
Current Financing Needs
$4 million to complete trial, submit, obtain regulatory approval
Current Timeline
Approximately 10 months to complete enrollment and follow up, 2 to 3 months to write report, tie up loose ends at study sites and submit to the FDA. Approval time and questions ranges from about 4 months to 9 months.
Current Investors
Mostly angel investors and several smaller institutions such as Iowa Lakes Capital, University of St. Thomas Norris Fund, and Blankney Group from Milwaukee
IP Status
10 issued patents in the US, 3 issued patents in Europe and Canada, one provisional patent filed in the US
Recent Milestones
New members adde to the Board of Directors, meeting with FDA to re-classify to a Class Ii device
Management Team Highlights
Kevin Dillon - CEO and Director, Mary Lach - CFO, Kelly Elliot - Clinical Study Director, John Erb - Director, Warren Watson - Director, Christopher Barys - Director, Steven Zenz - Director, Bruce Johnson - Chairman and Director
Kevin Dillon
CloSys Corporation
CEO 

Karen Drexler

Astia is an organization whose mission is to provide women-led startups access to capital resources and executive leadership. Astia was founded in 2013 and is based in San Francisco California with additional offices in New York New York and London United Kingdom. Astia typically provides access to capital to women-led life science companies through two programs: Astia Venture Lunches and Astia Angels and is in the process of developing a third program: Astia Fund. Companies that apply to Astia Venture Lunches will be vetted by Astia?s Expert Sift process. The selected companies are invited to present to a room of accredited investors: VCs and angels. Companies applying to Astia are also considered by Astia Angels and the investments from Astia Angels are typically under $1 million. Astia is stage agnostic though companies applying should be able to show traction and proof of concept. Companies can be global and must have at least one woman in a leadership position of significant influence and holding equity.
Astia Angels
Founder 

Dr Sean Du United States

Altravax is a privately held biopharmaceutical company focused on developing first-in-class biological products to fight infectious diseases or treat other indications. The Company has a robust pipeline of candidates at various preclinical stages of development including a therapeutic vaccine against chronic hepatitis B infection. Altravax seeks investment opportunities to develop these lead candidates for clinical testing.

Website:
www.altravax.com
Year Founded
2009
Biotech Subsector
Biotech Phase of Development
Technology Overview
: Altravax’s proprietary Immunogen Optimization System™ (IOS) offers unique opportunities to create many types of novel biopharmaceutical product candidates with significantly improved safety, efficacy, manufacturability, stability, and toxicity for preclinical evaluation in a cost-effective manner.
Supporting Metrics or Evidence
A novel therapeutic hepatitis B vaccine containing improved antigen sequences has shown the abilities to induce superior antigen-specific B-cell and T-cell immune responses in animal experiments. The vaccine could potentially break immune tolerance, restore T-cell exhaustion, and have a significant therapeutic impact in chronic hepatitis B patients
Current Timeline
24-30 months to IND and 4 years to human POC with sufficient funding in place.
Current Investors
Arthur Ventures & an angel investor
IP Status
US and PCT filed.
Altravax
Co-Founder, Chief Operator Officer 

Richard Duke United States

The Colorado Institute for Drug, Device and Diagnostic Development (CID4) is a 501(c)3 not-for-profit entity committed to economic development through the creation and funding of Colorado Life Science companies. Our goal is to efficiently transform emerging life science innovations into commercial successes. First, we use a rigorous review process and advisory panel to select promising post-proof-of-concept technologies from Colorado’s outstanding research institutions and start-up companies. Second, we fund and actively manage product development while taking an equity position in existing companies and in new companies that we found with the inventors. Third, we facilitate additional seed and/or grant funding to further develop our portfolio companies technologies. By augmenting the value of these innovations, we position our portfolio companies to attract series A financing from venture capitalists and/or partnering opportunities with established pharmaceutical and biotechnology companies. We have funded 9 early stage companies since June 2010 and these companies have raised more than $30 million in additional private capital and grant funding.

Website:
www.cid4.com
Year Founded
2009
Biotech Phase of Development
Technology Overview
CID4 has 9 portfolio companies and several project companies that it represents. The companies and technologies are: Sophono (marketed bone anchored hearing device); PeptiVir (pre-clinical stage, peptide-based vaccine platform for influenza, MERS, Ebola, RSV and HIV); Flashback (CipherSensor algorithm for use in medical devices that monitor vital signs); VetDC (FDA approved veterinary oncology product); KromaTiD (molecular diagnostics to detect chromosomal inversion mutations); Aurora Oncology (IND ready bladder cancer therapies); aktiVax (post-protoype, pre-filled syringes and biocompatible vial replacements); Fitbionic (marketed foot prostheses); Sapphire Technologies (post-prototype non-stick dental device for packing composite materials); ApopLogic (phase 1 lung cancer drug; IND-ready targeted biologic for cancer); MenoGeniX (phase 2 menopause hot flash therapy)
Alliance & Collaborations
Colorado Office of Economic Development, Fitzsimons Redevelopment Authority, SBA, Colo. BioSciences Assn., High Country Venture, CU, CSU Ventures
Supporting Metrics or Evidence
Since June 2010: (1) >150 companies reviewed by our technical and business advisory committee; (2) Technology and IP from public research institutions and private companies; (3) $3 million invested in 9 companies (2 started by CID4); (4) Our portfolio companies have raised an additional $30 million in follow-on financing and grants
Current Financing Needs
We are looking for $10 million in philanthropic, angel, corporate and/or venture funding to match $5 million in available State of Colorado ED grant funds
Current Timeline
N/A
Current Investors
Colorado Office of Economic Dev. ($5.1 million), Fitzsimons Redevelopment Authority ($1 million)
IP Status
All of our companies have issued patents
Recent Milestones
Completed our 9th investment.
Management Team Highlights
Our management team has an average of over 30 years in the biotechnology and medical device industry in both start-up and large companies
Colorado Institute for Drug Device and Diagnostic Development
Founder & CSO