David Joseph United States

Avisa Pharma™ Inc., (AVISA) is a Point Of Care, In-Vivo Platform Technology Company With An Innovative, Integrated System For The Rapid Detection And Monitoring Of Respiratory Diseases. A paradigm shift away from lab based In Vitro testing; an In Vivo, point of care, breath test that measures the whole lung, live organisms, not a single culture sample in a petri dish or PCR;for non sputum producers - the only test that can detect lung bacteria without a sputum culture; A razor/razorblade Model to Drive Rapid Market Penetration and Growth.

Focused initially on respiratory health, the clinical study strategy is to pursue fastest route to regulatory approvals, the detection of Tuberculosis (TB), followed by Healthcare Acquired Pneumonia (HCAP), Ventilator Associated Pneumonia (VAP), Cystic Fibrosis (CF) and COPD. These applications have the potential to help save millions of lives and millions of dollars in healthcare costs each year, and a multi billion $ market opportunity.  

$6 million Series A1 Preferred round underway, $4 million received from current investors exercising preemptive rights. Q1 2015 Avisa will be launching a 40 patient pilot TB study in South Africa.

Year Founded
2011
Main Sector
Medtech Subsector
Medtech Phase of Development
Technology Overview
The AVISAR Systemâ„¢ is drug device combination comprised of AV-U13, an inhalable urea solution, the portable AVISARâ„¢ Spec Laser Spectrophotometer and the Aeroneb Solo nebulizer. The AV BreathTestâ„¢ allows clinicians to assess the presence or absence of bacteria in the entire lung, non-invasively, within minutes and monitor therapy for better antibiotic stewardship. A paradigm shift away from lab based In Vitro testing. An In Vivo, point of care, breath test that measures the whole lung, live organisms, not a single culture sample in a petri dish or PCR. For non sputum producers - the only test that can detect lung bacteria without a sputum culture.
Alliance & Collaborations
None
Supporting Metrics or Evidence
Pre-clinical, Clinical
Current Financing Needs
Series A1 $6 million, $4 million raised from current investors
Current Timeline
PMA in 2017
Current Investors
Venture fund, private equity investors
IP Status
Issued and Pending Patents
Recent Milestones
Positive Clinical Data in Proof of Concept in Cystic Fibrosis clinical study
Management Team Highlights
CEO 35 years, four successful exits
Avisa Pharma Inc.
President - CEO 

Jeff June United States

Ischemia Care (ISC) is a clinical stage, capital efficient, venture capital backed, diagnostic laboratory company commercializing ISCDX, a blood test for cause of ischemic stroke (including atrial fibrillation or “AF”), leading to timely diagnosis and treatment, resulting in hospital cost savings and improved patient outcomes. ISC is executing on the Biomarkers of Acute Stroke Etiology (BASE) study , clinicaltrials.gov identifier NCT02014896 to support clinical adoption as an LDT through a company owned CLIA laboratory. ISC's initial focus is on the 40% (320K annually) ischemic strokes which are diagnosed as unkown cause (or "cryptogenic") as these patients typically are undertreaked and at a high risk for recurrence.

Stroke is the third leading cause of death worldwide with 20M annual events. In the US, there are 800K strokes, of which 195K are recurrent. Despite advances in imaging, cardiac monitoring, patient history assessment, and clinical examination, in 40% of ischemic strokes, the cause is unknown (or “cryptogenic”) leading to high recurrence and death.  There are no blood tests for cause of stroke. The identification of cause will change outcomes per Stroke Guidelines by adoption of “cause based” treatment regimen to prevent a more massive, debilitating, and costly recurrence. For example, identifying “undetected” AF in cryptogenic patients provides a 60% risk recurrence reduction.

Website:
www.iscdx.com
Year Founded
2009
Biotech Subsector
Biotech Phase of Development
Medtech Phase of Development
Technology Overview
Blood test for cause of stroke. The test (called ISCDX) detects immune responses by RNA expression related to causes of stroke, including AF, within minutes of event. ISCDX is ordered by a clinician at a hospital after a stroke has occurred, a tube of blood is drawn, sent to the ISC CLIA laboratory, results are reported to the physician during patient hospitalization , and paid through the hospital under existing reimbursement (DRG) codes. ISCDX may reduce cost by $7,000 per patient and increase hospital revenue.
Alliance & Collaborations
Medronic, Affymetric, Cleveland Clinic, MUSC, Allegahany Health Network, Albert Einstein Medical Center, UCLA.
Supporting Metrics or Evidence
14+ years, 600+ patients of data, 5 patents, $5M Federal Funding (pre licensing by ISC), and publications in major peer reviewed journals. Previous research has demonstrated sensitivity/ specificity > 95%. ISC reached milestones faster and with less investment than comparable exits.
Current Financing Needs
ISC is raising a $5M series C at $6.5M pre money, with $2.5M closed. ISC previously raised $2.3M in equity and $1.4M in non dilutive funding, further demonstrating commercial and technical merit.
Current Timeline
ISC is following proven commercial pathway. The BASE clinical trial will serve as a final clinical validation and build sales channel to commercially offer the ISCDX test through the company CLIA laboratory. This strategy is similar to companies such as Veracyte and Foundation Medicine (both 2013 IPOs).
Current Investors
Broadview Ventures, Cleveland Clinic (GCIC grant), Queen City Angels, Ohio Third Frontier, Accelerant Fund, and private individuals.
IP Status
5 patents in various stages of prosecution, international filings as well.
Management Team Highlights
Proven management team and board (2 IPOs, multiple exits, past president of AHA, chief of cardiology at Stanford, 4 VC directors), KOLs in the field of stroke (including author of the Stroke Guidelines), strategic support (Affymetrix, Medtronics), and leading stroke center directors.
Jeff June
Ischemia Care
LinkedIn logo CEO & Founder 

Byron Kalogerou United States

McDermott Will & Emery is a premier international law firm with a unique focus in representing life sciences companies and investors in a wide variety of transactional, intellectual property and regulatory matters.  Through our Life Sciences Entrepreneurs Acceleration Program ("LEAP") we provide early stage medical device, pharmaceutical, biotechnology and diagnostic companies access to sophisticated legal services.  Learn more here: http://www.mwe.com/leap/

Website:
www.mwe.com
Service Provider Type
Medtech Phase of Development
Unique Capabilities
Life Sciences Entrepreneurs Acceleration Program (LEAP)

McDermott Will & Emery is dedicated to investing in innovation and serving the early stage life sciences community that creates new and revolutionary products and services. We understand that sophisticated legal services are necessary to help these groundbreaking individuals and organizations succeed. McDermott is proud to have created the Life Sciences Entrepreneurs Acceleration Program (LEAP) to help qualifying entrepreneurs and young companies avoid costly mistakes and chart their courses to success by providing support and affordable access to strategic legal advice. We provide these organizations with high quality legal services during the earliest stages of corporate life through engagement incentives in the form of deferred fees, discounts, fixed-fee arrangements and/or awards.

We understand that early stage life sciences clients need legal advice in such complex areas as corporate formation, financing, intellectual property, licensing and collaborations, and employee benefits. Our Life Sciences Industry Group has a deep bench of lawyers that are highly regarded in these specific practices. Our corporate lawyers have demonstrated success in advising life sciences companies on the full range of transactional legal needs, including licensing and partnering, mergers and acquisitions, venture capital, public offerings and royalty stream financing. Our intellectual property lawyers are renowned for protecting the IP rights of our clients both in and out of court. Finally, McDermott is a pioneer in the field of employee benefits and has been advising life sciences companies on various compensation strategies to both secure and maintain leadership.

McDermott Will & Emery

Arnd Kaltofen Switzerland

VC fund focusing on investments in Switzerland and surounding areas

Investor Type
Biotech Phase of Development
Medtech Phase of Development
Capital Structure Preference
Investment Stage Preference
VI Partners
General Partner 

Mr Dmitry Kaminskiy Hong Kong SAR China

We are a Hong Kong-based venture fund management company focusing on mid- to long-term advanced technology investments at early stage. Through our partnership with the top analytical companies utilizing machine learning and large panel of experts, we can construct complex decision trees showing risk and return at every stage of company evolution. We routinely invest in both private and public companies specializing in biotechnology, drug discovery, personalized medicine, Big Data analysis, industrial expert systems and artificial intelligence. 

Mr Dmitry Kaminskiy
Deep Knowledge Ventures
LinkedIn logo Senior Partner 

Aaron Kantoff United States

Apple Tree Partners is a private equity fund that was established in 1999 and based in New York, NY, with satellite offices in Princeton, NJ, Cambridge, MA and Brussels, Belgium. The firm controls up to $1.75 billion in assets under management and makes equity investments ranging from $100,000 for academic spinouts to $150 million dollar in later stage deals. The firm seeks to make investments around the globe with a focus on creating and building companies located within the US and Europe.

Year Founded
1999
Investor Type
Biotech Phase of Development
Medtech Phase of Development
Capital Structure Preference
Investment Stage Preference
Apple Tree Partners
Vice President 

Jeff Karan

Mavericks Capital
Managing Partner 

Enoch Kariuki

H.I.G. BioVentures is the life science investment affiliate of H.I.G. Capital and has offices across the USA. H.I.G. BioVentures has assets under management of $4m and is investing from its second fund which closed at $268m in 212. The firm typically makes initial equity investments of $3-7m with the potential to invest up to $2m over the life of an investment. While most of H.I.G. BioVentures? portfolio companies are US-based the firm will consider opportunities worldwide.
H.I.G. BioVentures
Vice President 

Jonathan Kaufman United States

Development-stage pharmaceutical company with a platform technology to deliver novel therapeutics to the urinary bladder lumen for the treatment of inflammatory bladder conditions such as overactive bladder and interstitial cystitis. Our portfolio includes prodcuts in pase-I and phase-II clinical trials in the United States and overseas, as well as pre-clinical programs. We also have one program designated as orphan. In addition to therapeutics, Lipella also develops diagnostic agents to be used in connection with medical imaging.

Website:
www.lipella.com
Year Founded
2005
Biotech Subsector
Biotech Phase of Development
Medtech Phase of Development
Technology Overview
Platform technology for the local delivery of novel therapeutics to the urinary bladder
Alliance & Collaborations
Multiple
Current Financing Needs
Can be discussed
Current Investors
Private, non-institutional
IP Status
Multiple US patents, and US and international patent applications
Recent Milestones
LP-09 clinical trial completed 2013, LP-08 IND approved 2014
Management Team Highlights
Small, focused team
Lipella Pharmaceuticals Inc.
CEO 

John Kenney United States

Antibody Solutions is a premier developer of therapeutic, diagnostic and critical reagent antibodies. Our platforms include human antibodies from transgenic OmniRats™, Hybridoma Libraries™, and high-throughput flow-cytometry screening of cell-associated targets. We provide full technical support and project management with all services performed in the USA. 

Website:
www.antibody.com
Year Founded
1995
Service Provider Type
Medtech Subsector
Biotech Phase of Development
Unique Capabilities

Human Ab producing OmniRats™ 

Hybridoma Libraries™  

High-throughput flow-cytometry screening 

Proven record of success

In Vitro Ab Production

Proven track record of success

Antibody Solutions
President